Assessment and treatment in autism spectrum disorders: a focus on genetics and psychiatry.
Assessment and treatment in autism spectrum disorders: a focus on genetics and psychiatry.
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DOI：
10.1155/2012/242537
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Hellings, Jessica A
中科院分区：
文献类型：
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作者：
Butler, Merlin G;Youngs, Erin L;Hellings, Jessica A
自闭症谱系障碍（ASD）是一种神经行为障碍，其特征在于三个行为领域的异常，包括社会互动，受损的沟通和重复刻板行为。ASD影响大约1%的儿童，并且随着这些疾病的重要遗传机制而上升。我们回顾了目前的理解的作用，遗传和代谢因素有助于ASD与使用新的遗传技术。50%的人被诊断为染色体异常、小DNA缺失/重复、单基因疾病或代谢紊乱。遗传评估讨论沿着与精神病治疗和药物选择的方法来治疗相关的挑战行为或合并症中看到的ASD。我们强调根据目标症状群优先治疗的重要性，以及ASD患者的治疗顺序，因为治疗可能因患者而异。
Autism spectrum disorders (ASDs) are neurobehavioral disorders characterized by abnormalities in three behavioral domains including social interaction, impaired communication, and repetitive stereotypic behaviors. ASD affects approximately 1% of children and is on the rise with significant genetic mechanisms underlying these disorders. We review the current understanding of the role of genetic and metabolic factors contributing to ASD with the use of new genetic technology. Fifty percent is diagnosed with chromosomal abnormalities, small DNA deletions/duplications, single-gene conditions, or metabolic disturbances. Genetic evaluation is discussed along with psychiatric treatment and approaches for selection of medication to treat associated challenging behaviors or comorbidities seen in ASD. We emphasize the importance of prioritizing treatment based on target symptom clusters and in what order for individuals with ASD, as the treatment may vary from patient to patient.