Medical grade calcium sulfate hemihydrate in healing of human extraction sockets: Clinical and histological observations at 3 months
Medical grade calcium sulfate hemihydrate in healing of human extraction sockets: Clinical and histological observations at 3 months
复制标题
DOI：
10.1902/jop.2004.75.6.902
复制
发表时间：
2004-06-01
影响因子：
4.3
通讯作者：
Piattelli, A
中科院分区：
文献类型：
--
作者：
Guarnieri, R;Pecora, G;Piattelli, A
背景：拔牙后，拔牙部位牙槽骨的重塑和吸收是伤口愈合的特征。这会导致牙槽嵴体积减少，并且难以将种植体延迟放置在理想位置。医用级半水硫酸钙（MGCSH）已被提议作为拔牙窝中的移植材料，以尽量减少牙槽嵴体积的减少。本研究的目的是探讨MGCSH对intrasocket再生骨的组织病理学模式的影响，并从组织学上评估愈合的MGCSH移植拔牙窝网站postextraction.Methods：MGCSH移植在10个新鲜的人拔牙窝在10例。5个拔牙后牙槽作为对照。3个月时，从之前移植的部位钻取直径2.5 mm的圆柱形组织样本，然后放置植入物。将未脱钙的标本水平面横切，用固绿色、甲苯胺蓝和货车Kossa染色进行组织学和组织形态计量学检查。在所有水平切片中发现了具有层状排列的新形成骨，顶端、中间和冠状面区域之间没有差异。冠状面的平均骨小梁面积为58.6% +/- 9.2%;中等面为58.1% +/- 6.2%;顶端面为58.3% +/-7.8%。结论：MGCSH是一种理想的拔牙窝骨再生移植材料，因为它几乎是完全可吸收的，它允许一个新的松质骨排列在3个月。
Background: Following tooth extraction, remodeling and resorption of the alveolar bone at the extraction site characterize wound healing. This produces a reduction in ridge volume and difficulties in delayed placement of implants in an ideal position. Medical grade calcium sulfate hemihydrate (MGCSH) has been proposed as a graft material in extraction sockets to minimize the reduction in ridge volume. The aim of the present study was to investigate the influence of MGCSH on the histopathologic pattern of intrasocket regenerated bone and to evaluate histologically the healed MGCSH grafted extraction socket site 3 months postextraction.Methods: MGCSH was grafted in 10 fresh human extraction sockets in 10 patients. Five post-extraction sockets were used as controls. At 3 months a cylindrical tissue specimen, 2.5 mm in diameter, was trephined from the previously grafted site followed by implant placement. Non-decalcified specimens were sectioned at a cross-horizontal plane and stained with fast green, toluidine blue, and Van Kossa stains for histological and histomorphometrical examination.Results: Histologically, MGCSH was not observed in most of the specimens. Newly formed bone with lamellar arrangements was identified in all the horizontal sections with no difference between apical, medium, and coronal areas. The mean trabecular area in the coronal sections was 58.6% +/- 9.2%; in the medium sections, 58.1% +/- 6.2%; and in the apical sections, 58.3% +/- 7.8%. The differences were not statistically significant.Conclusion: MGCSH seems to be an ideal graft material in extraction socket bone regeneration because it is almost completely resorbable, and it allows a new trabecular bone arrangement at 3 months.