Growth of Argentinian girls with Turner syndrome
Growth of Argentinian girls with Turner syndrome
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DOI：
10.1080/03014469500004192
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发表时间：
1995-11-01
影响因子：
1.7
通讯作者：
Bergada, C
中科院分区：
文献类型：
--
作者：
GarciaRudaz, C;Martinez, AS;Bergada, C
对阿根廷254例特纳综合征患者的生长数据进行了分析，其中120例为XO核型，134例为其他染色体异常。出生体重和身高明显降低。90例患者从平均年龄14.0岁（SD 1.2）开始接受雌激素治疗，17例患者自发初潮。自发初潮的患者有一个小的生长突增。最终身高略高（139.8 cm SD 5.6），但与整个样本的平均成人身高（137.9 cm SD 5.7）无显著差异。平均成人身高比当地正常人群的平均值低3.73 SD。从出生到成熟的平均身高增长速度与其他样本中发现的非常相似。距离标准是通过将五次多项式拟合到每0.5岁的内插平均身高和原始SD来制备的。然后根据平滑值计算选定的百分位数。当地特纳综合征女孩和当地正常人群的成年身高差异与其他社区描述的特纳正常差异非常相似。这里提出的标准是有用的，用于评估特纳综合征患者从阿根廷，也可用于那些在其正常人群中具有相似的生长模式。
Growth data on 254 patients with Turner syndrome from Argentina-120 with XO karyotype and 134 with other chromosomal abnormalities-were analysed. Birth weight and height were significantly reduced. Ninety patients had received oestrogen treatment from a mean age of 14.0 years (SD 1.2) and 17 patients had spontaneous menarche. Patients who underwent spontaneous menarche had a small growth spurt. Final height was slightly higher (139.8 cm SD 5.6), though not significantly different from the mean adult height of the whole sample (137.9 cm SD 5.7). Mean adult height was 3.73 SD below mean of the normal local population. Mean height velocities from birth to maturity are very similar to those found in other samples. Distance standards were prepared by fitting a fifth-degree polynomial to the interpolated mean heights at each 0.5 year of age, and to the raw SD. Selected centiles were then calculated from the smoothed values. Differences between adult height in local Turner syndrome girls and local normal population are very similar to the same Turner-normal differences described in other communities. Standards presented here are useful for evaluating Turner syndrome patients from Argentina, and may also be used by those with similar growth pattern in their normal population.