ULTRASONOGRAPHIC MEASUREMENT OF THE COMMON CAROTID-ARTERY WALL THICKNESS IN HYPERCHOLESTEROLEMIC PATIENTS - A NEW MODEL FOR THE QUANTITATION AND FOLLOW-UP OF PRECLINICAL ATHEROSCLEROSIS IN LIVING HUMAN-SUBJECTS
ULTRASONOGRAPHIC MEASUREMENT OF THE COMMON CAROTID-ARTERY WALL THICKNESS IN HYPERCHOLESTEROLEMIC PATIENTS - A NEW MODEL FOR THE QUANTITATION AND FOLLOW-UP OF PRECLINICAL ATHEROSCLEROSIS IN LIVING HUMAN-SUBJECTS
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DOI：
10.1016/0021-9150(88)90176-1
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发表时间：
1988-04-01
期刊：
影响因子：
5.3
通讯作者：
PAOLETTI, R
中科院分区：
文献类型：
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作者：
POLI, A;TREMOLI, E;PAOLETTI, R
人体动脉的超声高分辨率B模式成像允许在体内准确且无创地确定内膜-中膜复合体的厚度。一个计算机辅助程序来测量这个参数在颈总动脉的水平。两次厚度测定之间的平均差异为4.6%。然后在一组高胆固醇血症患者中测量颈总动脉内膜-中层复合体的厚度。与对照组相比，这些患者的该参数显著更大（P < 0.001）。患者颈动脉树中小斑块的患病率也显著增加。结果显示，正常对照组内膜-中层复合体厚度随年龄增长而增加（r = 0.46，P < 0.05），而糖尿病组内膜-中层复合体厚度随年龄增长而增加（r = 0.46，P < 0.05）。在高胆固醇血症组中，男性患者和吸烟者的内膜-中膜复合体值更大。结论：高胆固醇血症患者颈总动脉内膜-中层复合体增厚。吸烟、男性性别和年龄增加了这种改变的程度。使用非侵入性技术测定该参数可能代表了体内监测人类早期动脉粥样硬化进展和/或消退的重要工具。
Ultrasound high resolution B-mode imaging of human arteries allows in vivo an accurate and non-invasive determination of the thickness of the intimal-medial complex. A computer assisted procedure to measure this parameter at the level of common carotid arteries was developed. The average difference between duplicate thickness determinations was 4.6%. The thickness of the intimal medial complex of common carotid arteries was then measured in a group of hypercholesterolemic patients. This parameter was significantly greater in these patients as compared to controls (P < 0.001). The prevalence of small plaques in the carotid arterial tree was also significantly increased in patients. Analysis of data showed that in controls, but not in patients, the thickness of the intimal medial complex increases with age (r = 0.46, P < 0.05). Within the hypercholesterolemic group, intimal-medial complex values were greater in male patients and in smokers. It is concluded that the common carotid arteries of hypercholesterolemic patients show thickening of the intimal-medial complex. Cigarette smoking, male sex and age increase the extent of this modification. The determination of this parameter using a non-invasive technique may represent an important tool to monitor in vivo the progression and/or the regression of early atherosclerosis in man.