Scalable Electrochemical Decarboxylative Olefination Driven by Alternating Polarity.
Scalable Electrochemical Decarboxylative Olefination Driven by Alternating Polarity.
复制标题
DOI：
10.1002/anie.202309157
复制
发表时间：
2023-09
影响因子：
--
通讯作者：
Alberto F. Garrido-Castro;Yuta Hioki;Y. Kusumoto;Kyohei Hayashi;Jeremy Griffin;Kaid C. Harper;Yuuki Kawamata;Phil S Baran
中科院分区：
文献类型：
--
作者：
Alberto F. Garrido-Castro;Yuta Hioki;Y. Kusumoto;Kyohei Hayashi;Jeremy Griffin;Kaid C. Harper;Yuuki Kawamata;Phil S Baran
本发明公开了一种温和的、可伸缩的(Kg)无金属烷基羧酸电化学脱羧制烯烃的方法。介绍了许多应用，其中这种转化可以简化烯烃的合成，并提供从简单的羧酸原料到有价值的烯烃的替代合成途径。这种可靠的方法依赖于交替的极性来保持电极表面的质量和局部pH，从而以前所未有的化学选择性加深了对Hofer-Moest工艺的理解。
A mild, scalable (kg) metal-free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access to valuable olefins from simple carboxylic acid feedstocks. This robust method relies on alternating polarity to maintain the quality of the electrode surface and local pH, providing a deeper understanding of the Hofer-Moest process with unprecedented chemoselectivity.