Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
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DOI：
10.1016/j.bbagen.2005.06.015
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发表时间：
2005-10-30
影响因子：
3
通讯作者：
Paquot, M
中科院分区：
文献类型：
--
作者：
Dufour, S;Deleu, M;Paquot, M
合成了表面蛋白的新的线性类似物。测定了它们的物理化学参数。结果表明，这些线型产物具有表面活性，但与环状化合物相比，它们的表面活性较低。并测定了其溶血活性。与环状表面蛋白相比，线性产物在测试的浓度范围内没有明显的溶血作用。此外，线性表面蛋白对Triton X-100诱导的溶血具有保护作用。发生这种保护作用的浓度与CMC直接相关，与产物的酰基链长成反比。在低渗介质中，具有较长酰基链的类似物有增加溶血的趋势，而链最短的产物则有降低溶血的趋势。(C)2005 Elsevier B.V.保留所有权利。
New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered compared to those of cyclic compounds. The hemolytic activities have also been assayed. In contrast with cyclic surfactins, no significant hemolysis occurs for the linear products in the range of concentrations tested. Moreover, a protective effect against Triton X-100 induced hemolysis has been highlighted for linear surfactins. The concentration at which this protective effect happens is correlated directly to the CMC, and inversely to the acyl chain length of the product. In a hypotonic medium, analogs having a long acyl chain tend to increase the hemolysis, meanwhile the product with the shortest chain tends to decrease it. (c) 2005 Elsevier B.V. All rights reserved.