The fundamental basis of inflammatory bowel disease
The fundamental basis of inflammatory bowel disease
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DOI：
10.1172/jci30587
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发表时间：
2007-03-01
影响因子：
15.9
通讯作者：
Mannon, Peter
中科院分区：
文献类型：
--
作者：
Strober, Warren;Fuss, Ivan;Mannon, Peter
关于炎症性肠病（IBD，包括溃疡性结肠炎和克罗恩病）发病机制的基本性质，出现了两种广泛的假设。第一种观点认为，粘膜免疫系统的原发性失调导致对正常微生物菌群的过度免疫反应。第二个提示肠道菌群组成的变化和/或上皮屏障功能紊乱会导致正常粘膜免疫系统的病理反应。在这里，我们检查这些假设，并得出结论，IBD的特点确实是异常的粘膜免疫反应，但微生物因素和上皮细胞异常可以促进这种反应。
Two broad hypotheses have arisen regarding the fundamental nature of the pathogenesis of inflammatory bowel diseases (IBDs, which include ulcerative colitis and Crohn disease). The first contends that primary dysregulation of the mucosal immune system leads to excessive immunologic responses to normal microflora. The second suggests that changes in the composition of gut microflora and/or deranged epithelial barrier function elicits pathologic responses from the normal mucosal immune system. Here we examine these hypotheses and conclude that IBD is indeed characterized by an abnormal mucosal immune response but that microbial factors and epithelial cell abnormalities can facilitate this response.