State-dependent and region-specific alterations of cerebellar connectivity across stable human wakefulness and NREM sleep states
State-dependent and region-specific alterations of cerebellar connectivity across stable human wakefulness and NREM sleep states
复制标题
在稳定的人类清醒状态和 NREM 睡眠状态下小脑连接的状态依赖性和区域特异性改变
DOI：
10.1016/j.neuroimage.2022.119823
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发表时间：
2022-12-22
期刊：
影响因子：
5.7
通讯作者：
Gao, Jia-Hong
中科院分区：
文献类型：
--
作者：
Liu, Jiayi;Zuo, Guangyuan;Gao, Jia-Hong
睡眠调节和功能可能依赖于整个大脑（包括小脑）的系统性协调。然而，小脑与其他大脑区域之间的相互作用是否以及如何在睡眠阶段发生变化，人们仍知之甚少。在此，我们利用从73名参与者在清醒和非快速眼动（NREM）睡眠期间采集的同步脑电图 - 功能性磁共振成像记录，构建了小脑与小脑内部、新皮质和皮质下区域的内在功能网络之间的连接。我们发现小脑连接呈现出睡眠依赖性的改变：清醒与N1/N2睡眠之间存在细微差异，N3睡眠相较于其他状态变化更大。还揭示了N2睡眠和N3睡眠之间特定区域的小脑连接变化：小脑内部连接普遍中断，边缘 - 小脑连接增强，以及小脑与特定空间新皮质的连接改变。进一步的相关性分析表明，小脑控制II网络与区域（包括岛叶、海马体和杏仁核）之间的功能连接与N3睡眠期间的δ波功率和N2睡眠期间的β波功率相关。这些发现系统地揭示了从清醒到深度睡眠内在网络中小脑连接的改变，并强调了小脑在睡眠调节和功能中的潜在作用。
Sleep regulation and functioning may rely on systematic coordination throughout the whole brain, including the cerebellum. However, whether and how interactions between the cerebellum and other brain regions vary across sleep stages remain poorly understood. Here, using simultaneous EEG-fMRI recordings captured from 73 partic-ipants during wakefulness and non-rapid eye movement (NREM) sleep, we constructed cerebellar connectivity among intrinsic functional networks with intra-cerebellar, neocortical and subcortical regions. We uncovered that cerebellar connectivity exhibited sleep-dependent alterations: slight differences between wakefulness and N1/N2 sleep and greater changes in N3 sleep than other states. Region-specific cerebellar connectivity changes between N2 sleep and N3 sleep were also revealed: general breakdown of intra-cerebellar connectivity, enhancement of limbic-cerebellar connectivity and alterations of cerebellar connectivity with spatially specific neocortices. Further correlation analysis showed that functional connectivity between the cerebellar Control II network and regions (including the insula, hippocampus, and amygdala) correlated with delta power during N3 and beta power during N2 sleep. These findings systematically reveal altered cerebellar connectivity among intrinsic net-works from wakefulness to deep sleep and highlight the potential role of the cerebellum in sleep regulation and functioning.