Pseudogenes in metazoa: Origin and features
Pseudogenes in metazoa: Origin and features
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DOI：
10.1093/bfgp/3.2.157
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发表时间：
2004-08-01
期刊：
影响因子：
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通讯作者：
Saccone, Cecilia
中科院分区：
文献类型：
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作者：
D'Errico, Ilenia;Gadaleta, Gemma;Saccone, Cecilia
完整的基因组序列及其注释在生物学中是一个相当大的资源，特别是在分子水平上理解遗传物质的全球结构方面。为什么一些真核生物基因组中含有大量明显不必要的DNA，即伪基因，而另一些基因组似乎投资于更有效的稀疏过程或配备了针对寄生虫分子的保护系统，这仍然是一个谜。为了在完全测序的基因组中识别伪基因，人们已经进行了几次全基因组调查，揭示了它们在数量和分布上的一些差异。由于伪基因是进化基因组学和比较基因组学中的重要资源，被称为“分子化石”，本文综述了不同伪基因的起源、特征、丰度和定位。作为产生加工假基因的基因的一个例子，还报告了作者实验室在研究线粒体生物发生的关键调控因子线粒体转录因子A(MtTFA)的核基因时获得的一些实验数据。
The complete genome sequences with their annotations are a considerable resource in biology, particularly in understanding the global structure of the genetic material at the molecular level. The reason why some eukaryotic genomes contain large quantities of apparently unnecessary DNA, namely pseudogenes, while others seem to invest in more efficient thinning processes or are equipped with protection systems against parasitic elements still remains a mystery.Several genome-wide surveys have been undertaken to identify pseudogenes in the completely sequenced genome, bringing to light some differences both in their amount and distribution. Since pseudogenes are important resources in evolutionary and comparative genomics — as ‘molecular fossils’—in this paper, a survey on the origins, features, abundance and localisation of the different pseudogenes is reported. As an example of genes producing processed pseudogenes, some experimental data obtained in the authors' laboratories from the study of a nuclear gene coding for the mitochondrial transcription factor A (mtTFA), a key regulator of mitochondrial biogenesis, are also reported.