Chemo- and site-selective derivatizations of natural products enabling biological studies.
Chemo- and site-selective derivatizations of natural products enabling biological studies.
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DOI：
10.1039/c3np70087a
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发表时间：
2014-03
影响因子：
11.9
通讯作者：
Romo D
中科院分区：
文献类型：
--
作者：
Robles O;Romo D
生物活性天然产物和衍生物仍然是发现疾病干预的新细胞靶点和开发新治疗剂的先导化合物的持久起点。前一个目标是通过从天然产物中合成生物活性细胞探针来实现的，从而能够通过经典的亲和层析或更新的蛋白质组谱方法来深入了解这些天然产物的作用机制。然而，由于这些天然物质的结构复杂性和广泛的官能团多样性，为这些目的直接和选择性地对天然产物进行改性仍然是一项挑战。缺乏可用于直接操作无保护的复杂小分子的选择性合成方法，特别是进行结构-活性关系研究和制备适当的细胞探针，最近得益于化学选择性合成方法学这一更广泛的新兴领域，已经开始得到解决。因此，新的试剂、催化剂和反应工艺使复杂的天然天然产物能够进行化学和现场选择性修饰。在这篇综述中，我们描述了最近在这一新兴领域中这些功能化战略的一些例子。
Bioactive natural products and derivatives remain an enduring starting point for the discovery of new cellular targets for disease intervention and lead compounds for the development of new therapeutic agents. The former goal is accomplished through the synthesis of bioactive cellular probes from natural products enabling insights into the mechanism of action of these natural products by classical affinity chromatography or more recent proteome profiling methods. However, the direct and selective modification of native natural products for these purposes remains a challenge due to the structural complexity and the wide functional group diversity found in these natural substances. The lack of selective synthetic methods available to directly manipulate unprotected complex small molecules, in particular to perform structure-activity relationship studies and prepare appropriate cellular probes, has recently begun to be addressed benefitting from the broader emerging area of chemoselective synthetic methodology. Thus, new reagents, catalysts and reaction processes are enabling both chemo- and site-selective modifications of complex, native natural products. In this review, we describe selected recent examples of these functionalization strategies in this emerging area.
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影响因子：
56.9
作者：
Chen, Mark S.;White, M. Christina
通讯作者：
White, M. Christina
影响因子：
15
作者：
Fujiwara, Yuta;Dixon, Janice A.;Rodriguez, Rodrigo A.;Baxter, Ryan D.;Dixon, Darryl D.;Collins, Michael R.;Blackmond, Donna G.;Baran, Phil S.
通讯作者：
Baran, Phil S.
影响因子：
15
作者：
Han S;Miller SJ
通讯作者：
Miller SJ
影响因子：
3.2
作者：
Alexander, MD;Burkart, MD;La Clair, JJ
通讯作者：
La Clair, JJ
影响因子：
15
作者：
Hayakawa, Y;Kim, JW;Seto, H
通讯作者：
Seto, H