Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study
Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study
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DOI：
10.1016/j.joca.2017.01.014
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发表时间：
2017-07-01
影响因子：
7
通讯作者：
Spoendlin, J.
中科院分区：
文献类型：
--
作者：
Frey, N.;Hugle, T.;Spoendlin, J.
目的：临床前证据表明，胆固醇水平升高可能参与了手骨关节炎（HOA）的病理生理学，但来自观察性研究的证据仍然很少。我们的目的是分析之间的关联，红细胞血症和事件HOA.Design：我们进行了匹配（1：1）的病例对照研究，使用英国的临床实践研究数据链（CPRD）。病例为1995年至2014年期间发生HOA诊断的30-89岁患者。在多变量条件Logistic回归分析中，我们计算了依性别、年龄、既往血吸虫病持续时间和近期他汀类药物治疗分类的血吸虫病患者发生HOA的比值比（OR）。在19,590例病例和19,590例对照中，我们观察到高脂血症患者HOA的风险增加（OR 1.37，95%置信区间（CI）1.28-1.47）。因此，在我们的研究人群中，所有HOA病例中，3.6%可能归因于胆固醇血症（人群归因风险）的存在。大多数HOA患者为老年人，但HOA与糖尿病之间的相关性强度与年龄增加呈负相关，29-49岁患者的OR最高为1.72（95%CI 1.24-2.38）。分类由以前的类胡萝卜素血症的持续时间，以及亚类胡萝卜素血症的患者到那些最近没有他汀类药物的使用并没有有意义地改变效果estimate.Conclusions：我们的研究结果表明，类胡萝卜素血症可能是一个独立的危险因素新发HOA。(C)2017国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA.Design: We conducted a matched (1: 1) case-control study using the UK-based Clinical Practice Research Datalink (CPRD). Cases were patients aged 30-89 years with an incident diagnosis of HOA between 1995 and 2014. In multivariable conditional logistic regression analyses, we calculated odds ratios (OR) for incident HOA in patients with hyperlipidaemia, categorized by gender, age, previous duration of hyperlipidaemia, and recent statin treatment.Results: Among 19,590 cases and 19,590 controls, we observed an increased risk of HOA in patients with hyperlipidaemia (OR 1.37, 95% confidence intervals (CI) 1.28-1.47), when compared to patients without hyperlipidaemia. Thus, of all HOA cases in our study population, 3.6% may have been attributable to the presence of hyperlipidaemia (population attributable risk). Most patients with HOA were elderly, but the strength of the association between HOA and hyperlipidaemia inversely correlated with increasing age, with the highest OR of 1.72 (95% CI 1.24-2.38) in patients aged 29-49 years. Categorization by previous hyperlipidaemia duration, as well as sub-classification of patients with hyperlipidaemia into those with and without recent statin use did not meaningfully change the effect estimate.Conclusions: Our results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA.(C) 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.