AUTORADIOGRAPHIC AND ELECTRON-MICROSCOPIC STUDY OF RETINO-HYPOTHALAMIC CONNECTIONS
AUTORADIOGRAPHIC AND ELECTRON-MICROSCOPIC STUDY OF RETINO-HYPOTHALAMIC CONNECTIONS
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DOI：
10.1007/bf00307084
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发表时间：
1972-01-01
期刊：
影响因子：
--
通讯作者：
COWAN, WM
中科院分区：
文献类型：
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作者：
HENDRICKSON, AE;WAGONER, N;COWAN, WM
已经在大鼠、豚鼠、兔、猫和猴的玻璃体内注射 3 H-亮氨酸或 3 H-脯氨酸后通过放射自显影研究了视网膜-下丘脑连接，并在豚鼠和猴的单侧眼睛摘除后通过电子显微镜研究了视网膜-下丘脑连接。在每个被检查的物种中，都发现了从视网膜到视交叉上核的直接投射的证据，但没有到下丘脑其他区域的直接投射。视交叉上核的投射总是双侧的（即使在白化豚鼠中，视网膜投射的所有其他组成部分都是交叉的），但从我们放射自显影照片中的颗粒计数来看，对侧核的输入似乎是同侧的两倍。大多数视网膜纤维似乎终止于细胞核的腹侧部分，在那里它们在小树突分支或树突棘上形成不对称突触。讨论了视网膜投射到视交叉上核在介导各种光诱导的神经内分泌反应中的可能作用。
Retino-hypothalamic connections have been studied autoradiographically in the rat, guinea pig, rabbit, cat and monkey following the intravitreal injection of3H-leucine or3H-proline, and electron microscopically following unilateral eye removal in the guinea pig and monkey. In each of the species examined evidence has been found for a direct projection from the retina to the suprachiasmatic nucleus,but to no other region of the hypothalamus. The projection to the suprachiasmatic nucleus is always bilateral (even in the albino guinea pig, in which all other components of the retinal projection are crossed) but from grain counts in our autoradiographs it appears that the input to the contralateral nucleus is about twice as heavy as that on the ipsilateral side. Most of the retinal fibers appear to terminate within the ventral part of the nucleus where they form asymmetric synapses either upon small dendritic branches or dendritic spines. The possible role of this retinal projection to the suprachiasmatic nucleus in mediating a variety of light-induced neuroendocrine responses is discussed.