Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.
Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.
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DOI：
10.1111/adb.12405
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发表时间：
2017-09
影响因子：
3.4
通讯作者：
Le Merrer J
中科院分区：
文献类型：
--
作者：
Becker JAJ;Kieffer BL;Le Merrer J
统一的成瘾理论受到不同药物类别的药物寻求行为和神经生物学适应的挑战，特别是麻醉剂和精神兴奋剂。我们之前的研究表明，长期戒断阿片类药物会导致小鼠的绝望行为和社交退缩，我们在扩展的杏仁核中发现了一种转录特征，这种特征也存在于戒断尼古丁、四氢大麻酚（THC）和酒精的动物身上。在这里，我们研究了长期戒断这4种药物是否也具有共同的行为特征，并最终与戒断原型精神兴奋剂可卡因不同。在吗啡、尼古丁、四氢大麻酚和酒精戒断小鼠中，我们发现类似的社会认知降低、运动刻板印象增加和焦虑增加，并伴有相关的c-fos反应改变。然而，对可卡因的长期戒断导致了在各个层面上明显不同的、主要是相反的适应，包括行为反应、神经元激活和基因表达。总之，这些数据进一步证明了在动机/情感大脑回路中形成的对阿片类药物、尼古丁、四氢大麻酚和酒精的长期戒断的共同特征的存在。然而，在我们的模型中，这些不适用于可卡因，支持精神兴奋剂滥用的独特机制的概念。
Unified theories of addiction are challenged by differing drug-seeking behaviors and neurobiological adaptations across drug classes, particularly for narcotics and psychostimulants. We previously showed that protracted abstinence to opiates leads to despair behavior and social withdrawal in mice, and we identified a transcriptional signature in the extended amygdala that was also present in animals abstinent from nicotine, i9-tetrahydrocannabinol (THC) and alcohol. Here we examined whether protracted abstinence to these 4 drugs would also share common behavioral features, and eventually differ from abstinence to the prototypic psychostimulant cocaine. We found similar reduced social recognition, increased motor stereotypies, and increased anxiety with relevant c-fos response alterations in morphine, nicotine, THC and alcohol abstinent mice. Protracted abstinence to cocaine, however, led to strikingly distinct, mostly opposing adaptations at all levels, including behavioral responses, neuronal activation and gene expression. Together, these data further document the existence of common hallmarks for protracted abstinence to opiates, nicotine, THC and alcohol that develop within motivation/emotion brain circuits. In our model however, these do not apply to cocaine, supporting the notion of unique mechanisms in psychostimulant abuse.
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影响因子：
3.4
作者：
Ayranci, G.;Befort, K.;Lutz, P. -E.
通讯作者：
Lutz, P. -E.
DOI：
10.1111/j.1530-0277.2010.01392.x
发表时间：
2011-04-01
影响因子：
3.2
作者：
Economidou, Daina;Cippitelli, Andrea;Ciccocioppo, Roberto
通讯作者：
Ciccocioppo, Roberto
影响因子：
3.7
作者：
Cippitelli A;Astarita G;Duranti A;Caprioli G;Ubaldi M;Stopponi S;Kallupi M;Sagratini G;Rodrìguez de Fonseca F;Piomelli D;Ciccocioppo R
通讯作者：
Ciccocioppo R
影响因子：
7.6
作者：
Becker, Jerome A. J.;Clesse, Daniel;Kieffer, Brigitte L.
通讯作者：
Kieffer, Brigitte L.
影响因子：
3.7
作者：
El Hage C;Rappeneau V;Etievant A;Morel AL;Scarna H;Zimmer L;Bérod A
通讯作者：
Bérod A