Calcium channel blockers and myocardial infarction. A hypothesis formulated but not yet tested.
Calcium channel blockers and myocardial infarction. A hypothesis formulated but not yet tested.
复制标题
钙通道阻滞剂和心肌梗塞。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
C. Hennekens
中科院分区：
文献类型：
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作者：
J. Buring;R. Glynn;C. Hennekens
在本周的《美国医学会杂志》上，Psaty及其同事1介绍了一项病例对照研究的结果，该研究提出了高血压患者使用钙通道阻滞剂是否会增加心肌梗死风险的可能性，但无法明确评估。这项回顾性研究在普吉特海湾健康合作社的登记者中进行，比较了心肌梗死患者（病例）和非心肌梗死患者（对照组）既往使用各种抗高血压药物治疗的情况。作者报告，与单独使用利尿剂治疗的高血压患者相比，使用钙通道阻滞剂治疗的高血压患者发生心肌梗死的风险增加约60%（风险比=1.6; 95%置信区间[CI]，1.1 - 2.3），在高剂量治疗的患者中，这种明显的不良反应甚至更大。这是P620。不幸的是，在最近的一次科学会议上，媒体报道了这些发现的介绍，引发了这些用户的关注，
In this week's JAMA , Psaty and colleagues 1 present findings from a case-control study that raise the possibility, but cannot evaluate definitively, whether calcium channel blockers prescribed for patients with hypertension increase risk of myocardial infarction. This retrospective study among enrollees of the Group Health Cooperative of Puget Sound compared those who had suffered a myocardial infarction (cases) with those who had not (controls), with respect to their prior use of various antihypertensive drug therapies. The authors reported that risk of myocardial infarction increased about 60% (risk ratio=1.6; 95% confidence interval [CI], 1.1 to 2.3) among hypertensive patients treated with a calcium channel blocker compared with those treated with diuretics alone, and this apparent adverse effect was even greater among those treated with high doses. See also p 620. Unfortunately, media reporting of the presentation of these findings at a recent scientific meeting triggered concern among users of these and
老年人高血压药物选择的趋势。
DOI：
10.1161/01.hyp.25.5.1045
发表时间：
1995
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
Monane,M;Glynn,RJ;Gurwitz,JH;Bohn,RL;Levin,R;Avorn,J
通讯作者：
Avorn,J