AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.
AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.
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AEG-1 表达与人胶质瘤组织中 CD133 和 PPP6c 水平相关
DOI：
10.7555/jbr.28.20140015
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发表时间：
2014-09
影响因子：
2.3
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Guo J;Chen X;Xi R;Chang Y;Zhang X;Zhang X
星形胶质细胞升高基因-1（AEG-1）与多种人类肿瘤的发生、发展有关。本研究旨在探讨AEG-1在脑胶质瘤中的意义，并探讨AEG-1与脑胶质瘤细胞放射抗性的关系。免疫组化染色显示AEG-1、CD 133和PPP 6c蛋白在胶质瘤组织中表达强度明显增强，主要表达于胞浆。AEG-1、CD 133和PPP 6c的表达率分别为85.9%（67/78）、60.3%（47/78）和65.8%（51/78）。AEG-1表达与年龄（r = 0.227，P = 0.045）、临床分期（r = 0.491，P<0.001）和临床分级（r = 0.450，P<0.001）相关。 AEG-1的表达与其他临床病理参数无相关性（P>0.05）。AEG-1与CD 133（r = 0.240，P = 0.035）和PPP 6c（r = 0.250，P = 0.027）的表达呈正相关。 此外，检索到的TCGA数据暗示AEG-1和PPP 6c基因组改变在胶质母细胞瘤中同时发生。我们的研究结果表明，AEG-1与CD 133和AEG-1的表达呈正相关。它可能在胶质瘤的进展中发挥重要作用，并可能成为化学耐药性和放射耐药性的潜在新标志物。
Abstract Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.