Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results.
Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results.
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DOI：
10.1161/jaha.112.000019
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发表时间：
2013-02-22
影响因子：
5.4
通讯作者：
Heistad D
中科院分区：
文献类型：
--
作者：
Hasan DM;Chalouhi N;Jabbour P;Dumont AS;Kung DK;Magnotta VA;Young WL;Hashimoto T;Richard Winn H;Heistad D
炎症细胞和分子可能在脑动脉瘤的形成和破裂中发挥关键作用。最近，一项流行病学研究报告称乙酰水杨酸（ASA）可降低动脉瘤破裂的风险。本研究的目的是利用放射线照相和组织学技术确定 ASA 对人脑动脉瘤壁中炎症细胞和分子的影响。 11 名前瞻性入组的患有未破裂颅内动脉瘤的患者被随机分为 ASA 治疗组（每天 81 mg）（n=6）和未治疗（对照组）组（n=5）。使用 Ferumoxytol 增强 MRI 对动脉瘤进行基线成像，以估计巨噬细胞的摄取。 3个月后，患者在进行显微手术夹闭之前重新成像。收集动脉瘤组织，用环氧合酶-1 (COX-1)、环氧合酶-2 (COX-2)、微粒体前列腺素 E2 合酶-1 (mPGES-1) 和巨噬细胞的单克隆抗体进行免疫染色。 ASA 治疗 3 个月后，观察到 Ferumoxytol 增强 MRI 信号强度下降。 ASA 组中 COX-2（但不是 COX-1）、mPGES-1 和巨噬细胞的表达低于对照组。这项研究提供了初步的放射学和组织学证据，表明 ASA 可以减轻人脑动脉瘤壁的炎症过程。网址：http://www.clinicaltrials.gov。唯一标识符：NCT01710072。
Inflammatory cells and molecules may play a critical role in formation and rupture of cerebral aneurysms. Recently, an epidemiologic study reported that acetylsalicylic acid (ASA) decreases the risk of aneurysm rupture. The goal of this study was to determine the effects of ASA on inflammatory cells and molecules in the walls of human cerebral aneurysms, using radiographic and histological techniques. Eleven prospectively enrolled patients harboring unruptured intracranial aneurysms were randomized into an ASA‐treated (81 mg daily) group (n=6) and an untreated (control) group (n=5). Aneurysms were imaged at baseline using ferumoxytol‐enhanced MRI to estimate uptake by macrophages. After 3 months, patients were reimaged before undergoing microsurgical clipping. Aneurysm tissues were collected for immunostaining with monoclonal antibodies for cyclooxygenase‐1 (COX‐1), cyclooxygenase‐2 (COX‐2), microsomal prostaglandin E2 synthase‐1 (mPGES‐1), and macrophages. A decrease in signal intensity on ferumoxytol‐enhanced MRI was observed after 3 months of ASA treatment. Expression of COX‐2 (but not COX‐1), mPGES‐1, and macrophages was lower in the ASA group than in the control group. This study provides preliminary radiographical and histological evidence that ASA may attenuate the inflammatory process in the walls of human cerebral aneurysms. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01710072.