Comparative antibacterial effects of amoxycillin, amoxycillin/clavulanic acid and cefotaxime against Enterobacteriaceae as determined by turbidimetry, morphology and viable count.
Comparative antibacterial effects of amoxycillin, amoxycillin/clavulanic acid and cefotaxime against Enterobacteriaceae as determined by turbidimetry, morphology and viable count.
复制标题
通过比浊法、形态学和活菌计数测定阿莫西林、阿莫西林/克拉维酸和头孢噻肟对肠杆菌科细菌的抗菌作用比较。
DOI：
10.1159/000238400
复制
发表时间：
1986
期刊：
影响因子：
3.3
通讯作者：
P. Hunter
中科院分区：
文献类型：
--
作者：
J. M. Wilson;P. Hunter
与阿莫西林相比，头孢噻肟对肠杆菌科细菌的 MIC 值极低，但使用比浊法和活菌计数方法进行的抗菌活性研究表明，头孢噻肟没有优势。使用恒定的抗生素浓度和改变浓度来模拟体内条件，已经证明阿莫西林和阿莫西林/克拉维酸具有优异的杀灭率。即使在大大超过 MIC 的水平下，头孢噻肟仍具有缓慢的杀菌活性，并且可能与该化合物在较宽浓度范围内的细丝形成相关。
Cefotaxime has extremely low MIC values in comparison with amoxycillin against Enterobacteriaceae, but studies of antibacterial activity using turbidimetric and viable count methods show no advantage for cefotaxime. Superior rates of killing have been demonstrated for amoxycillin and amoxycillin/clavulanic acid using both constant antibiotic concentrations and changing concentrations to simulate conditions in vivo. Slow bactericidal activity was seen with cefotaxime even at levels greatly in excess of the MIC and could be correlated with filament formation by this compound over a wide range of concentrations.