Last piece of the puzzle: lead-assisted assembly of an arsenopalladate nanostar as an antitumor metallodrug
Last piece of the puzzle: lead-assisted assembly of an arsenopalladate nanostar as an antitumor metallodrug
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DOI：
10.1039/d4qi00026a
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发表时间：
2024-01-27
影响因子：
7
通讯作者：
Yang，Peng
中科院分区：
文献类型：
--
作者：
Zhao，Yue;Li，Cheng-Lan;Yang，Peng
打破高对称性和低能量的简单而不灵活的结构是坚韧的，但值得，例如多钯酸盐（POP）的立方体拓扑结构。在这项工作中，砷钯酸盐的杂金属模板支架提供了三个纳米立方体[MIVPd12O8（AsO4）8]12−（M = SnIV，CeIV和PbIV）和长期寻找的纳米星[PbIVPd15O10（AsO4）10]16−。适当的电荷和PbIV的半径同时满足立方和星星原型的不寻常的主客体组装。更重要的是首次成功制备了甲基膦酸酯封端的[Pd15O10（MePO3）10]10− POP。根据可调的杂金属和杂基团，所制备的POP是显示结构依赖性抗肿瘤活性的理想对象。研究表明，ROS介导的砷功能介导的细胞凋亡是其对不同类型肿瘤具有显著抑制作用的主要机制，这预示着下一代POP基抗肿瘤金属药物的设计理念。
It is tough, but worth it, to break the simple and inflexible structure of high symmetry and low energy, such as the cuboid topology of polyoxopalladates (POPs). In this work, the heterometal-templated scaffold of arsenopalladates has afforded three nanocubes of [MIVPd12O8(AsO4)8]12− (M = SnIV, CeIV, and PbIV) and the long-sought nanostar of [PbIVPd15O10(AsO4)10]16−. The appropriate charge and radius of PbIV satisfied the uncommon host–guest assembly of both cubic and star archetypes simultaneously. More than that is the successful preparation of the methylphosphonate-capped [Pd15O10(MePO3)10]10− POP for the first time. According to the adjustable heterometals and heterogroups, the as-made POPs represent ideal subjects to reveal structure-dependent antitumor activity. It turns out that ROS-induced apoptosis mediated by arsenate functions is mainly responsible for the significant inhibition against cancers of different types, which heralds the design philosophy of POP-based antitumor metallodrugs of the next generation.