In search of a function for the Ras-like GTPase Rap1
In search of a function for the Ras-like GTPase Rap1
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DOI：
10.1016/s0014-5793(97)00324-4
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发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Zwartkruis, F
中科院分区：
文献类型：
--
作者：
Bos, JL;Franke, B;Zwartkruis, F
Rap 1（Krev-1）是一个小的GT3，首先被鉴定为K-ras的转化抑制因子。这种GTPase与Ras非常相似，特别是在效应区，但其功能仍然难以捉摸。最近在寻找Rap 1功能方面取得的进展来自于一种测量Rap 1激活的新型测定方法的开发。使用该测定，在用各种激动剂刺激后在人血小板和中性粒细胞中观察到Rap 1的活化。我们推测Rap 1在这些细胞的专门功能之一中起作用。(C)1997年欧洲生物化学学会联合会。
Rap1 (Krev-1) is a small GTPase first identified as a transformation suppressor of K-ras. This GTPase is very similar to Ras, particularly in the effector region, but its function is still elusive, Recent progress in the search for Rap1 function has come from the development of a novel assay to measure Rap1 activation. Using this assay activation of Rap1 was observed in human platelets and neutrophils after stimulation with various agonists, We speculate that Rapl plays a role in one of the specialised functions of these cells. (C) 1997 Federation of European Biochemical Societies.