Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?

Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?
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DOI:
10.1016/j.semcdb.2017.06.024
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发表时间:
2018-08
影响因子:
7.3
通讯作者:
Brandizzi F
Brandizzi F
中科院分区:
生物学2区
文献类型:
--
作者:
Brandizzi F

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大约三分之一的细胞蛋白质组的生物发生在内质网(ER)中启动,内质网将蛋白质输出到高尔基体以分选到它们的最终目的地。而不是站在ER与其他分泌膜(例如,内体、质膜),ER对于非分泌细胞器如线粒体、过氧化物酶体和叶绿体的稳态也是重要的。虽然植物ER如何与大多数非分泌膜相互作用在很大程度上是未知的,但ER到高尔基体转运的机制的知识相对更先进。事实上,在过去的15年左右,大量令人兴奋的结果有助于与非植物物种进行比较,但也突出了植物ER-高尔基体界面的复杂性,它具有独特的功能。本文综述了植物内质网-高尔基体运输的研究结果,主要集中在模式物种拟南芥中COPII介导的运输研究。
The biogenesis of about one third of the cellular proteome is initiated in the endoplasmic reticulum (ER), which exports proteins to the Golgi apparatus for sorting to their final destination. Not with standing the close proximity of the ER with other secretory membranes (e.g., endosomes, plasma membrane), the ER is also important for the homeostasis of non-secretory organelles such as mitochondria, peroxisomes, and chloroplasts. While how the plant ER interacts with most of the non-secretory membranes is largely unknown, the knowledge on the mechanisms for ER-to-Golgi transport is relatively more advanced. Indeed, over the last fifteen years or so, a large number of exciting results have contributed to draw parallels with non-plant species but also to highlight the complexity of the plant ER-Golgi interface, which bears unique features. This review reports and discusses results on plant ER-to-Golgi traffic, focusing mainly on research on COPII-mediated transport in the model species Arabidopsis thaliana.
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