Evidence for local immunoglobulin synthesis in periodontitis.
Evidence for local immunoglobulin synthesis in periodontitis.
复制标题
牙周炎局部免疫球蛋白合成的证据。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
R. Yukna
中科院分区：
文献类型：
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作者：
Bruce M. Lovelace;James J. Thompson;R. Yukna
牙周炎病变的特征是浆细胞浸润增加。这些细胞的数量随着疾病的严重程度而增加，并且在组织培养中已经显示牙龈浆细胞体外合成免疫球蛋白。本研究将牙龈和血清免疫球蛋白水平相关联，以反映体内免疫球蛋白的产生。采用电免疫分析技术测定血清和牙龈IgG浓度同时相对于参考白蛋白水平在16例牙周炎患者。结果表明，局部免疫球蛋白的合成和积累发生在牙龈部位。结果表明，牙周炎患者牙龈中IgG的平均74.56%是局部来源的。
Periodontitis lesions are characterized by an increased plasma cell infiltrate. These cells have been shown to increase in number with the severity of the disease and in vitro synthesis of immunoglobulins by gingival plasma cells has been shown in tissue culture. This study correlated gingival and serum immunoglobulin levels to reflect the in vivo production of immunoglobulin. An electroimmunoassay technique was employed to determine serum and gingival IgG concentrations simultaneously relative to reference albumin levels in 16 patients with periodontitis. Results indicated that local immunoglobulin synthesis and accumulation occurs at the gingival site. Data obtained demonstrated that an average of 74.56% of the IgG found in gingiva from periodontitis patients was of local origin.
使用 DNA 扩增方法进行自身免疫性疾病的临床诊断。
影响因子：
2.7
作者：
Fox,RI;Dotan,I;Compton,T;Fei,HM;Hamer,M;Saito,I
通讯作者：
Saito,I