Alternative early life vaccination programs for companion animals
Alternative early life vaccination programs for companion animals
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DOI：
10.1016/j.jcpa.2007.04.020
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发表时间：
2007-07-01
影响因子：
0.8
通讯作者：
Poulet, H.
中科院分区：
文献类型：
--
作者：
Poulet, H.
本文报告了一项小猫多组分免疫的实验性攻毒研究。7 - 9周龄、无特定病原体的小猫接受两次注射（间隔4周）以最低保护剂量配制的无佐剂、多组分疫苗。在接种后4周或1年，用单个传染性病原体对小猫进行攻毒。在两种情况下，疫苗接种诱导了对猫细小病毒攻毒的完全保护，但在1年时，对猫疱疹病毒、猫杯状病毒和Chlanydophila fielis的保护不如疫苗接种后4周那么强。在第一次加强疫苗接种的正常时间保护性免疫力下降的证明表明，carlier接种该加强疫苗（4-6月龄）可能提供更好的保护。母源性抗体（NIDA）对小猫疫苗接种的影响通过进行相同的实验来确定，但在怀孕期间接种疫苗的母后所生小猫。在第0天（第一次接种时）、第28天（第二次接种时）和第42天测量这些小猫对特定疫苗组分的血清抗体滴度。有异质性的MDA转移到小猫在一窝，窝之间。当在8周龄和12周龄接种疫苗时，MDA可能中和小猫在第一次接种疫苗时的血清学应答，偶尔也会中和第二次接种疫苗时的血清学应答。这一发现支持了最近的建议，即在16周龄时接种主要系列中的最终疫苗。(c)2007爱思唯尔有限公司保留所有权利。
An experimental challenge Study of multicomponent vaccination of kittens is reported. Seven-to-nine week old,,specific pathogen-free kittens received two injections (4 weeks apart) of non-adjuvanted, multicomponent vaccine formulated at the minimum protective dose. Kittens were challenged at 4 weeks or I year post-vaccination with individual infectious agents. Vaccination induced complete protection against challenge from felinc parvovirus on both occasions but at 1 year, the protection against feline herpesvirus, feline calicivirtts and Chlanydophila fielis was not as strong as 4 weeks after vaccination. This demonstration of a decline in protective immunity at the normal time of administration of the first booster vaccine suggests that carlier administration of this booster (at 4-6 months of age) may provide better protection. The effect of maternally derived antibody (NIDA) on kitten vaccination was determined by conducting an identical experiment but with kittens born to queens vaccinated during pregnancy. Serum antibody titres to specific vaccine components were measured in these kittens on day 0 (time of first vaccination), day 28 (time of second vaccination) and day 42. There was heterogeneity in transfer of MDA to kittens within a litter, and between litters. MDA may neutralize the serological response of kittens on the first, and occasionally the second, occasion of vaccination when vaccination is performed at 8 and 12 weeks of age, This finding underpins recent recommendations that the final vaccination in the primary series be administered at 16 weeks of age. (c) 2007 Elsevier Ltd. All rights reserved.