EXPRESSION OF C-FOS PROTEIN IN THE NUCLEUS-TRACTUS-SOLITARIUS IN RESPONSE TO PHYSIOLOGICAL ACTIVATION OF CAROTID BARORECEPTORS
EXPRESSION OF C-FOS PROTEIN IN THE NUCLEUS-TRACTUS-SOLITARIUS IN RESPONSE TO PHYSIOLOGICAL ACTIVATION OF CAROTID BARORECEPTORS
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DOI：
10.1016/0306-4522(95)00217-7
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发表时间：
1995-11-01
期刊：
影响因子：
3.3
通讯作者：
SEAGARD, JL
中科院分区：
文献类型：
--
作者：
DEAN, C;SEAGARD, JL
本研究采用单侧生理压力刺激血管隔离颈动脉窦结合c-fos免疫组织化学方法，对麻醉、迷走神经切断犬孤束核内由颈动脉压力感受器激活的神经元进行定位。颈动脉压力感受器刺激主要激活孤束核尾侧连合和内侧亚核中的神经元。在孤束核的中间核和吻侧核，颈动脉压力感受器刺激激活了背侧和内侧亚核的神经元。本研究结果还表明，孤束核神经元的不同亚群可能被不同压力阈值的压力感受器激活。本研究中c-fos免疫组织化学的使用使颈动脉压力感受性反射通路中延髓背侧神经元种群的确定成为可能。这些结果还表明，不同压力阈值的颈动脉压力感受器有不同的投射。
This study has utilized unilateral physiological pressure stimulation of a vascularly isolated carotid sinus combined with c-fos immunohistochemistry to locate neurons of the nucleus tractus solitarius which are activated by carotid baroreceptors in the anesthetized, vagotomized dog. Carotid baroreceptor stimulation primarily activated neurons in the ipsilateral commissural and medial subnuclei of the caudal nucleus tractus solitarius. In the intermediate and rostral nucleus tractus solitarius, carotid baroreceptor stimulation activated neurons in the dorsal and medial subnuclei. Results from this study also suggested that different subgroups of nucleus tractus solitarius neurons may be activated by baroreceptors with different pressure thresholds.The use of c-fos immunohistochemistry in this study has enabled the definition of populations of dorsal medullary neurons in the carotid baroreflex pathway. The results also suggest a different projection of carotid baroreceptors with different pressure thresholds.