Fabrication of porous synthetic polymer scaffolds for tissue engineering
Fabrication of porous synthetic polymer scaffolds for tissue engineering
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DOI：
10.1177/0021955x14531002
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发表时间：
2015-03-01
影响因子：
2.5
通讯作者：
Turng, Lih-Sheng
中科院分区：
文献类型：
--
作者：
Mi, Hao-Yang;Jing, Xin;Turng, Lih-Sheng
组织工程学为用人工替代物替代受损组织提供了一种新的、有前途的方法。多孔合成的生物可降解聚合物由于其微观结构、生物相容性、生物降解性和低成本而成为这种替代的首选材料。支架作为组织工程的重要组成部分，起着人工细胞外基质的作用，为细胞的迁移、分化和繁殖提供支持。然而，可行支架的制造在临床和学术环境中都是一个挑战。溶剂浇注/颗粒浸出、热诱导相分离(TIPS)、静电纺丝、气体发泡和快速成型(添加剂制造)等方法已被开发或引入用于支架制造。每种方法都有自己的优点和缺点。本文对常用的合成聚合物支架制作方法进行了详细的介绍和讨论，并对不同支架制作方法的结合、不同材料的结合以及对现有支架制作方法的改进等支架制作方面的最新进展进行了综述。
Tissue engineering provides a novel and promising approach to replace damaged tissue with an artificial substitute. Porous synthetic biodegradable polymers are the preferred materials for this substitution due to their microstructure, biocompatibility, biodegradability, and low cost. As a crucial element in tissue engineering, a scaffold acts as an artificial extracellular matrix (ECM) and provides support for cell migration, differentiation, and reproduction. The fabrication of viable scaffolds, however, has been a challenge in both clinical and academic settings. Methods such as solvent casting/particle leaching, thermally induced phase separation (TIPS), electrospinning, gas foaming, and rapid prototyping (additive manufacturing) have been developed or introduced for scaffold fabrication. Each method has its own advantages and disadvantages. In this review, the commonly used synthetic polymer scaffold fabrication methods will be introduced and discussed in detail, and recent progress regarding scaffold fabricationsuch as combining different scaffold fabrication methods, combining various materials, and improving current scaffold fabrication methodswill be reviewed as well.