AN ANTIMITOTIC AND CYTOTOXIC CHALCONE FROM FISSISTIGMA-LANUGINOSUM
AN ANTIMITOTIC AND CYTOTOXIC CHALCONE FROM FISSISTIGMA-LANUGINOSUM
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DOI：
10.1021/np50122a002
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发表时间：
1995-08-01
期刊：
影响因子：
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通讯作者：
PAIS, M
中科院分区：
文献类型：
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作者：
ALIAS, Y;AWANG, K;PAIS, M
对瓜馥木的乙酸乙酯提取物进行生物测定引导的分级分离导致分离出已知的查耳酮柄蛋白[1]，其抑制微管蛋白组装成微管（IC 50值为300 μ M）。从相同的乙酸乙酯萃取物中，还得到了两个新的对KB细胞具有细胞毒性的缩合查耳酮，fissistin [2]和isofissistin [3]，以及无活性的dihydropedicin [4]和6，7-dimethoxy-5，8-dihydroxyflavone [5]。此外，从生物碱提取物中还分离出了氨基醌类化合物6，8和9。这些化合物是人工产物，分别通过用NH4OH处理1、4和2制备。新化合物的结构经波谱方法，特别是2DNMR确证。
Bioassay-guided fractionation of an ethyl acetate extract of Fissistigma lanuginosum led to the isolation of the known chalcone pedicin [1], which inhibited tubulin assembly into microtubules (IC50 value of 300 mu M). From the same EtOAc fraction, two new condensed chalcones, fissistin [2] and isofissistin [3], which showed cycotoxicity against KB cells, were also obtained, together with the inactive dihydropedicin [4] and 6,7-dimethoxy-5,8-dihydroxyflavone [5] In addition, the aminoquinones 6, 8, and 9 were isolated from the alkaloid extract. These compounds were artifacts, prepared by treatment of 1, 4, and 2, respectively, with NH4OH. The structures of the new compounds were elucidated by spectral methods, especially 2D nmr.