Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability
Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability
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DOI：
10.1016/j.jpsychires.2020.01.015
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发表时间：
2020-04-01
影响因子：
4.8
通讯作者：
Winkelman, John W.
中科院分区：
文献类型：
--
作者：
Eddie, David;Bentley, Kate H.;Winkelman, John W.
目前尚不清楚在重度抑郁症（MDD）和失眠症中观察到的神经生物学功能障碍是共同的还是独立的基础。本研究旨在探索心率变异性（HRV）-一种广泛使用的神经生物学功能生物标志物-MDD，失眠和健康对照个体之间的差异，同时清醒和不同的睡眠阶段（REM，N2），目的是提高我们对抑郁症和失眠症共同神经生物学因素的理解。参与者是73名接受家庭多导睡眠描记术的成年人。所有持续时间大于或等于5分钟的N2和REM睡眠时期均被识别用于HRV分析。此外，为每个参与者定义了单个清醒时期。从清醒到N2睡眠，以及从清醒到REM睡眠，HRV指标的变化表明参与者经历了交感神经唤醒的减少和副交感神经唤醒的增加。然而，与假设相反，在HRV中没有观察到组间差异。虽然目前的研究结果不支持MDD和失眠之间的碎片神经生物学通路的假设，但有必要开展更多的工作来促进我们对这些常见的，使人衰弱的，经常同时发生的精神疾病的神经生物学基础的理解，以提高早期发现并确定这些疾病的新干预目标。
It remains unclear whether neurobiological dysfunction observed in major depressive disorder (MDD) and insomnia is an expression of common or independent bases. The present investigation sought to explore differences in heart rate variability (HRV)-a widely utilized biomarker of neurobiological functioning-among individuals with MDD, insomnia, and healthy controls, while awake and during distinct sleep stages (REM, N2), with the goal of improving our understanding of shared neurobiological factors in depression and insomnia. Participants were 73 adults who underwent home polysomnography. All N2 and REM sleep epochs with a duration greater than or equal to 5 min were identified for HRV analysis. Additionally, a single waking epoch was defined for each participant. From waking to N2 sleep, and waking to REM sleep, changes in HRV indices indicated participants experienced reductions in sympathetic arousal and increases in parasympathetic arousal. Contrary to hypotheses, however, no between group differences were observed in HRV. Though the present findings do not support the hypotheses of a shard neurobiological pathway between MDD and insomnia, more work is warranted to advance our understanding of the neurobiological bases of these common, debilitating, and frequently co-occurring psychiatric conditions, to improve early detection and identify novel intervention targets for these disorders.