Hsp90 and client protein maturation.
Hsp90 and client protein maturation.
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DOI：
10.1007/978-1-61779-295-3_3
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bolon, Daniel N
中科院分区：
文献类型：
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作者：
Wayne, Natalie;Mishra, Parul;Bolon, Daniel N
热休克蛋白90(Hsp90)是一种分子伴侣，帮助一组有限的底物蛋白成熟，这些底物蛋白统称为客户。大多数已确定的Hsp90客户都参与了信号转导，包括许多类固醇激素受体和激酶。少数Hsp90客户可被分类为非信号转导蛋白，包括端粒酶、囊性纤维化跨膜电导调节因子(CFTR)和主要组织相容性复合体(MHC)的抗原肽。由于Hsp90客户是癌症和囊性纤维化的病原体，近年来对Hsp90的研究有所加强。我们回顾了Hsp90研究在每一类客户(激酶、激素受体和非信号转导客户)中的历史轨迹，并强调了当前积极研究的领域。
Heat shock protein 90 (Hsp90) is a molecular chaperone that assists in the maturation of a limited set of substrate proteins that are collectively referred to as clients. The majority of identified Hsp90 clients are involved in signal transduction including many steroid hormone receptors and kinases. A handful of Hsp90 clients can be classified as non-signal transduction proteins including telomerase, cystic fibrosis transmembrane conductance regulator (CFTR), and antigenic peptides destined for major histocompatibility complex (MHC). Because Hsp90 clients are causative agents in cancer and cystic fibrosis, research on Hsp90 has intensified in recent years. We review the historical path of Hsp90 research within each class of client (kinase, hormone receptor, and non-signal transduction clients) and highlight current areas of active investigation.