Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs
Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs
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DOI：
10.1016/j.clim.2007.11.008
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发表时间：
2008-03-01
影响因子：
8.6
通讯作者：
Ayyoub, Maha
中科院分区：
文献类型：
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作者：
Tosello, Valeria;Odunsi, Kunle;Ayyoub, Maha
自然树突状细胞在控制自身耐受性方面起着至关重要的作用，但在体内由树突状细胞介导的抑制作用的部位仍然存在争议。我们之前已经报道过在人类循环淋巴细胞中存在不同的幼稚和记忆Treg群体。在这里，我们发现记忆树含有高比例的炎性趋化因子表达细胞，并包括两个在淋巴趋化因子受体CCR7表达上不同的群体，它们代表了传统CCR7(+)中央记忆(CM)和CCR7(-)效应记忆(EM)T细胞的对应。CM和EM Tregs具有相似的体外抑制功能，但与传统的CD4(+)T细胞相比，EM群体在Tregs中更突出，是卵巢肿瘤中发现的主要Treg亚群。我们的数据表明，CM和EM Treg之间的分工确保了淋巴和周围部位(包括肿瘤部位)的耐受性。(C)2007 Elsevier Inc.保留所有权利。
Natural Tregs play an essential role in controlling self-tolerance but the in vivo sites of Treg-mediated suppression remain controversial. We have previously reported tion of distinct naive and memory Treg populations in human circulating lymphocytes. Here we show that memory Tregs contain high proportions of inflammatory chemokine-expressing cells and comprise two populations that differ in the expression of the lymphoid chemokine receptor CCR7 and represent the counterparts of conventional CCR7(+) central memory (CM) and CCR7(-) effector memory (EM) Tcells. CM and EM Tregs exert comparable ex vivo suppressor functions but the EM population is more prominent among Tregs as compared to conventional CD4(+) Tcells, and is the main Treg subset found in ovarian tumors. Our data suggest that a division of labor between CM and EM Tregs ensures tolerance at lymphoid and peripheral locations including tumor sites. (c) 2007 Elsevier Inc. All rights reserved.