Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes
Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes
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DOI：
10.1016/j.biopsych.2004.01.021
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发表时间：
2004-05-01
影响因子：
10.6
通讯作者：
Julien, P
中科院分区：
文献类型：
--
作者：
Frasure-Smith, N;Lespérance, F;Julien, P
多不饱和脂肪酸（PUFAs）是固有的细胞膜成分，密切参与神经传递和受体功能。较低的omega-3水平与冠状动脉疾病（CAD）风险增加、冠心病患者心脏事件增加和抑郁相关。我们试图研究急性冠脉综合征（ACS）恢复期患者抑郁与血清omega-3和omega-6 PUFAs水平之间的关系。我们对54对年龄和性别匹配的患者进行了一项病例对照研究，研究对象为ACS后约2个月的血清PUFA水平和当前重度抑郁症。结果。抑郁症患者的总omega-3和二十二碳六烯酸（DHA）浓度显著低于对照组，花生四烯酸（AA）与DHA、AA与二十碳五烯酸（EPA）、n-3与n-6的比值显著高于对照组。在抑郁症的任何潜在危险或保护因素方面没有基线差异。结果与先前关于无冠心病的抑郁症患者的报道一致，也与有关ω -3水平与冠心病事件风险的文献一致。饮食、遗传和激素因素都可能在抑郁症和CAD中发挥作用。需要前瞻性研究和随机试验来帮助阐明相互关系。
Background Polyunsaturated fatty acids (PUFAs) are intrinsic cell membrane components and closely involved in neurotransmission and receptor function. Lower omega-3 levels are associated with increased risk of coronary artery disease (CAD), increases in cardiac events in CAD patients, and depression. We sought to examine relationships between depression and serum levels of omega-3 and omega-6 PUFAs in patients recovering from acute coronary syndromes (ACS).Methods., We carried out a case-control study of serum PUFA levels and current major depression in 54 age- and sex-matched pairs approximately 2 months following ACS!Results. Depressed patients bad significantly lower concentrations of total omega-3 and docosahexaenoic acid (DHA), and higher ratios of arachidonic acid (AA) to DHA, AA to eicosapentaenoic acid (EPA), and n-3 to n-6 than controls. There were no baseline differences in any potential risk or protective factors for depression.Conclusions. Results are consistent with previous reports in depressed patients without CAD, and with literature concerning omega-3 levels and risk of CAD events. Dietary, genetic, and hormonal factors may all play a role in both depression and CAD. Both prospective studies and randomized trials are needed to help clarify the interrelationships.