Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.
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DOI：
10.1016/j.semcancer.2012.04.001
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发表时间：
2012-10
影响因子：
14.5
通讯作者：
Weinberg RA
中科院分区：
文献类型：
--
作者：
Scheel C;Weinberg RA
上皮-间充质转化（EMT）赋予上皮细胞间充质特性，并与癌细胞获得侵袭性性状密切相关。EMT程序由一组多效性作用转录因子（TF）协调。这些EMT-TF的作用使转移的早期步骤成为可能：局部侵袭和随后癌细胞向远处部位的传播。然而，在大多数恶性肿瘤中，微转移沉积物随后生长成肉眼可见的转移对临床进展的影响最大。这种转移性“定植”反映了播散的肿瘤细胞适应外来组织微环境的能力。转移的生长也被认为与自我更新有关，自我更新是癌症干细胞（CSC）的定义细胞特征，也称为肿瘤起始细胞。重要的是，EMTFs和自我更新之间的分子联系已经出现，表明EMT程序在转移级联反应的早期和晚期都起着关键作用。调节EMTTF激活的遗传和表观遗传机制及其诱导的性状是正在深入研究的领域。这些研究可能为治疗干预提供新的机会，并有助于克服肿瘤异质性和治疗耐药性。
The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of aggressive traits by carcinoma cells. EMT programs are orchestrated by a set of pleiotropically acting transcription factors (TFs). The actions of these EMT-TFs enable the early steps of metastasis: local invasion and subsequent dissemination of carcinoma cells to distant sites. However, in most malignancies, the subsequent outgrowth of micrometastatic deposits into macroscopic metastases has the greatest impact on clinical progression. Such metastatic “colonization” reflects the ability of disseminated tumor cells to adapt to a foreign tissue microenvironment. The outgrowth of a metastasis is also thought to be associated with self-renewal, the defining cellular trait of cancer stem cells (CSCs), also termed tumor-initiating cells. Importantly, molecular links between EMTTFs and self-renewal have emerged, suggesting that EMT programs play critical roles both early and late in the metastatic cascade. The genetic and epigenetic mechanisms that regulate the activation of EMTTFs and the traits they induce are areas under intensive investigation. Such studies may provide new opportunities for therapeutic intervention and help to overcome tumor heterogeneity and therapeutic resistance.
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DOI：
10.1038/jid.2008.445
发表时间：
2009-07
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Chien AJ;Conrad WH;Moon RT
通讯作者：
Moon RT
影响因子：
64.5
作者：
Goessling W;North TE;Loewer S;Lord AM;Lee S;Stoick-Cooper CL;Weidinger G;Puder M;Daley GQ;Moon RT;Zon LI
通讯作者：
Zon LI
影响因子：
2.8
作者：
Brabletz, T;Jung, A;Kirchner, T
通讯作者：
Kirchner, T
影响因子：
11.2
作者：
Chaffer, Christine L.;Brennan, Janelle P.;Williams, Elizabeth D.
通讯作者：
Williams, Elizabeth D.
影响因子：
4
作者：
Bolós, V;Peinado, H;Cano, A
通讯作者：
Cano, A