Sustained release properties of polyelectrolyte multilayer capsules
Sustained release properties of polyelectrolyte multilayer capsules
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DOI：
10.1021/jp002184
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发表时间：
2001-03-29
影响因子：
3.3
通讯作者：
Möhwald, H
中科院分区：
文献类型：
--
作者：
Antipov, AA;Sukhorukov, GB;Möhwald, H
使用带相反电荷的聚电解质的逐层（LbL）组装来涂覆荧光素颗粒。这些颗粒的尺寸为4-9 μ m，通过在pH 2下沉淀荧光素来制备。使用聚苯乙烯磺酸盐（PSS）和聚烯丙基胺（PAH）在荧光素核上形成壳层。在pH 8下，通过作为去猝灭的结果的荧光强度的增加来监测在核溶解期间荧光素分子通过壳的渗透。发现足以维持荧光素释放的荧光层的数量为8-10。增加层的数量延长核心溶解时间分钟。厚度为20 nm的多层膜对荧光素的透过率约为10（-9）m/s。的释放曲线和可能的应用程序的LBL方法的壳形成，以控制释放性能的包埋材料的特点进行了概述。
Layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was used to coat fluorescein particles. These particles, with a size of 4-9 mum, were prepared by precipitation of fluorescein at pH 2. Polystyrensulfonate (PSS) and polyallylamine (PAH) were used to form a polyelectrolyte shell on the fluorescein core. The permeation of fluorescein molecules through the polyelectrolyte shell during core dissolution was monitored at pH 8 by the increasing fluorescence intensity as a result of dequenching. The number of polyelectrolyte layers sufficient to sustain fluorescein release was found to be 8-10. Increasing the number of layers prolonged the core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm for fluorescein is about 10(-9) m/s. The features of the release profile and possible applications of the LbL method for shell formation in order to control release properties for entrapped materials are outlined.