COLON CANCER OVERVIEW
COLON CANCER OVERVIEW
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DOI：
10.1002/1097-0142(19920901)70:3
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发表时间：
1992-09-01
期刊：
影响因子：
6.2
通讯作者：
GREENWALD, P
中科院分区：
文献类型：
--
作者：
GREENWALD, P
国家癌症研究所目前支持的预防研究范围包括饮食调整和癌症筛查试验的临床评估，流行病学研究，新的化学预防疗法的开发，以及使用先进的分子生物学技术来探测结直肠腺瘤的遗传决定因素。在流行病学和实验研究中，结肠直肠癌经常与高脂肪低纤维饮食有关。最近启动的大肠腺瘤性息肉复发的III期饮食干预研究将调查低脂高纤维水果和蔬菜丰富的饮食模式对降低息肉复发率的潜在益处。化学预防计划目前正在支持四项III期对照临床干预试验，研究β-胡萝卜素、吡罗昔康、钙和钙加纤维对先前患有腺瘤的人的结直肠癌的抑癌作用。一项拟议中的早期检测试验将筛查结直肠癌、前列腺癌、肺癌和卵巢癌。发病率和死亡率趋势的比较表明结直肠癌检测和治疗的进展。
The scope of current prevention research support by the National Cancer Institute includes the clinical assessment of dietary modifications and cancer screening trials, epidemiologic studies, development of new chemopreventive therapies, and the use of advanced molecular biologic technologies to probe the genetic determinants of colorectal adenomas. Colorectal cancer frequently has been associated with high-fat low-fiber diets in epidemiologic and experimental studies. A recently initiated Phase III Dietary Intervention Study of Recurrence of Large Bowel Adenomatous Polyps will investigate the potential benefits of a low-fat high-fiber fruit-and-vegetable-enriched eating pattern to decrease the polyp recurrence rate. The Chemoprevention Program currently is supporting four Phase III controlled clinical intervention trials investigating the cancer-inhibiting effects on colorectal cancer of beta-carotene, piroxicam, calcium, and calcium plus fiber in persons with previous adenomas. A proposed early detection trial will screen for colorectal, prostate, lung, and ovarian cancers. A comparison of incidence and mortality trends indicates progress in colorectal cancer detection and therapy.