Role of airway epithelial cells in the development of different asthma phenotypes
Role of airway epithelial cells in the development of different asthma phenotypes
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DOI：
10.1016/j.cellsig.2019.109523
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发表时间：
2020-05-01
影响因子：
4.8
通讯作者：
Garn, Holger
中科院分区：
文献类型：
--
作者：
Potaczek, Daniel P.;Miethe, Sarah;Garn, Holger
术语（支气管）哮喘描述了一种包括多种疾病表型的疾病综合征，所有这些疾病表型都以支气管上皮慢性炎症为特征，并伴有各种随后的功能后果。因此，导气管上皮是本病复杂病理变化的主要定位。在这方面，支气管上皮细胞不是被动地受到免疫过程诱导的炎症机制的影响，而是积极参与疾病发展的所有步骤，从开始和延续到慢性化。近年来研究发现，支气管上皮细胞具有高度的结构和功能多样性和可塑性，表观遗传机制在这些过程的调控中起着至关重要的作用。因此，支气管上皮的不同功能活动参与不同哮喘表型和/或疾病阶段的发展是非常合理的。这篇综述文章将讨论目前关于这一主题的知识。
The term (bronchial) asthma describes a disorder syndrome that comprises several disease phenotypes, all characterized by chronic inflammation in the bronchial epithelium, with a variety of subsequent functional consequences. Thus, the epithelium in the conducting airways is the main localization of the complex pathological changes in the disease. In this regard, bronchial epithelial cells are not passively affected by inflammatory mechanisms induced by immunological processes but rather actively involved in all steps of disease development from initiation and perpetuation to chronification. In recent years it turned out that bronchial epithelial cells show a high level of structural and functional diversity and plasticity with epigenetic mechanisms playing a crucial role in the regulation of these processes. Thus, it is quite reasonable that differential functional activities of the bronchial epithelium are involved in the development of different asthma phenotypes and/or stages of disease. The current knowledge on this topic will be discussed in this review article.