Lymph node hyalinization in elderly Japanese
Lymph node hyalinization in elderly Japanese
复制标题
DOI：
10.14670/hh-18.1169
复制
发表时间：
2003-10-01
影响因子：
2
通讯作者：
Kohama, G
中科院分区：
文献类型：
--
作者：
Taniguchi, I;Murakami, G;Kohama, G
淋巴结透明化已被全面调查，使用标本从老年日本人和白色美国人。洋葱皮样病变和相关的网状区域常见于胸淋巴结的髓窦（纵隔型玻璃样变），而嗜酸性、玻璃样和斑点状病变常见于盆腔淋巴结的B淋巴细胞区域（盆腔型玻璃样变）。纵隔型透明化由细胶原纤维（直径约50 nm）组成，而骨盆型透明化有粗纤维（直径约150 nm）。这种差异似乎与胸部和骨盆区域之间血管壁复合胶原纤维的差异一致。盆腔型玻璃样变常见于或偶见于其他淋巴结，如颈部、腋窝、腹部和腹股沟淋巴结，尤以美国白色人为多。纵隔型玻璃样变，通常与充满炭疽巨噬细胞的窦相结合，在日本人中比在白色美国人中更常见。煤尘肺似乎与玻璃样变的发病机制有关。另一方面，由于病变对因子VIII免疫组织化学呈弱阳性，并且病变位于沿着薄血管，因此骨盆型玻璃样变似乎起源于结节皮质中的血管变性。由于玻璃样变的发生率高，在淋巴结总体积中所占比例大，因此玻璃样变似乎是随着年龄的增长而降低淋巴结过滤功能和破坏淋巴结的主要事件之一。
Lymph node hyalinization has been comprehensively investigated using specimens obtained from elderly Japanese and white Americans. Onion-peel lesions and associated meshwork areas were often found in the medullary sinus of the thoracic node (mediastinal-type hyalinization), while eosinophilic, glassy and spotty lesions were consistently seen in B lymphocyte areas of the pelvic node (pelvic-type hyalinization). The mediastinal-type hyalinization was comprised of thin collagen fibrils (ca 50 nm in diameter), whereas the pelvic-type hyalinization had thick fibrils (ca 150 nm in diameter). This difference seemed to be consistent with a difference in composite collagen fibrils of vascular walls between the thoracic and pelvic regions. The pelvic-type hyalinization was often or sometimes seen in other nodes, such as cervical, axillary, abdominal and inguinal nodes, especially in white Americans. The mediastinal-type hyalinization, usually in combination with a sinus filled with anthracotic macrophages, tended to be observed in Japanese more frequently than in white Americans. Anthracosis seemed to be connected to the pathogenesis of the hyalinization. On the other hand, because the lesion was weakly positive for Factor VIII immunohistochemistry and because lesions were located along thin vessels, the pelvic-type hyalinization seemed to originate from vascular degeneration in the nodal cortex. Due to the high incidence and large proportion in total volume of the node, the hyalinization seems to be one of the major events that diminish the nodal filtration function and ruin the node with aging.