Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia
Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia
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DOI：
10.1530/eje.0.1480559
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发表时间：
2003-05-01
影响因子：
5.8
通讯作者：
Nau, R
中科院分区：
文献类型：
--
作者：
Michel, U;Ebert, S;Nau, R
目的：激活素是多种细胞类型的生长和分化因子，最近被发现与炎症过程有关。缺乏激活素及其结合蛋白卵泡抑素（FS）的临床数据。我们测量了诊断为败血症的患者的血清激活素和 FS 水平。患者和测量：对不同年龄、不同形式败血症和不同临床结果的 8 名男性和 7 名女性患者进行了调查，并与年龄和性别匹配的健康对照进行比较。败血症期间测定血清 FS、激活素、C 反应蛋白 (CRP) 浓度和血液白细胞计数。结果：败血症患者的最大激活素浓度中位数是年龄和性别匹配的健康对照者的 3.9 倍（P < 0.01）；最大 FS 浓度的中位数高出 2.6 倍 (P < 0.01)。脓毒症患者的激活素最高增加约 15.8 倍，而 FS 比正常情况增加最多 13.2 倍。 FS、激活素和 CRP 血清水平通常相互平行，但与白细胞计数或临床结果不相关。结论：诊断为败血症的患者中激活素和 FS 的循环浓度升高，这与在全身炎症反应中的潜在作用一致。
Objective: Activin is a growth and differentiation factor of many cell types, and has recently been implicated in inflammatory processes. Clinical data linking activin and its binding protein, follistatin (FS), are lacking. We measured serum levels of activin and FS in patients diagnosed with septicemia.Patients and measurements: Eight male and seven female patients of different ages, various forms of septicemia and different clinical outcome were investigated and compared with age- and sex-matched healthy controls. Serum concentrations of FS, activin, C-reactive protein (CRP) and blood leukocyte counts were determined during septicemia.Results: The median of the maximum activin concentrations of septicemic patients was 3.9-fold higher than in age- and sex-matched healthy control subjects (P < 0.01); the median of the maximum FS concentrations was 2.6-fold higher (P < 0.01). The highest increase of activin in septicemic patients was approximately 15.8-fold, whereas FS increased by up to 13.2-fold above normal. FS, activin and CRP serum levels generally paralleled each other, but were not correlated with leukocyte counts or clinical outcome.Conclusions: Circulatory concentrations of activin and FS are elevated in patients diagnosed with septicemia, consistent with potential roles in the systemic inflammatory response.