Environmental and occupational exposures and serum PCB concentrations and patterns among Mohawk men at Akwesasne
Environmental and occupational exposures and serum PCB concentrations and patterns among Mohawk men at Akwesasne
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DOI：
10.1038/sj.jes.7500500
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发表时间：
2007-05-01
影响因子：
4.5
通讯作者：
Tarbell, Alice
中科院分区：
文献类型：
--
作者：
Fitzgerald, Edward F.;Hwang, Syni-An;Tarbell, Alice
进行了一项研究，以解决如何鱼类消费，职业和室外空气影响血清PCB浓度和同系物模式之间的139个美洲原住民男子生活在三个危险废物场的问题。他们被采访了他们的居住，职业和饮食史，并捐赠了20毫升静脉血用于同源特定的PCB分析。通过计算它们之间的欧几里得距离，测量在血清中发现的同系物模式和在当地环境样品中检测到的同系物模式之间的相似性。结果表明，血清中的多氯联苯浓度呈正相关的累积终身暴露于本地鱼类消费和职业。然而，在过去10年中生活在Raquette Point的参与者，这是保护区最接近危险废物场地的地区，也是在室外空气中发现多氯联苯水平升高的唯一地点，没有比生活在Akwesasne其他地方的参与者更高的血清多氯联苯浓度。关于模式匹配，莫霍克男子与最大的累积终身接触多氯联苯从当地鱼类消费的血清多氯联苯同系物模式，更接近类似的鱼从近海的危险废物的网站之一，比男人谁吃当地的鱼少。同样，职业性接触多氯联苯的莫霍克族男子比没有职业性接触的人更有可能具有与当地使用的商用多氯联苯混合物Aroclor 1248相似的血清多氯联苯同系物模式。只有当这些人吃相对较少的当地鱼类时，拉凯特角居民的血清PCB同系物模式才更接近室外空气中的模式。这项研究是第一批证明室外空气可能影响血清PCB同系物模式的研究之一，至少在没有大量食用鱼类的情况下是如此。
A study was conducted to address the question of how fish consumption, occupation, and outdoor air affected serum PCB concentrations and congener patterns among 139 Native American men living near three hazardous waste sites. They were interviewed about their residential, occupational, and dietary histories, and donated 20 ml of venous blood for congener-specific PCB analysis. The similarity in the congener pattern between that found in the serum and that detected in local environmental samples was measured by calculating the Euclidean distance between them. The results indicated that serum PCB concentrations were positively associated with cumulative lifetime exposures to PCBs from local fish consumption and occupation. However, participants who lived in the last 10 years at Raquette Point, which is the area of the Reserve closest to the hazardous waste sites and the only location where elevated levels of PCBs were found in outdoor air, did not have higher serum PCB concentrations than participants who lived elsewhere at Akwesasne. Regarding pattern matching, Mohawk men with the greatest cumulative lifetime exposure to PCBs from local fish consumption had a serum PCB congener pattern that more closely resembled that in fish caught off-shore from one of the hazardous waste sites than did men who ate less local fish. Similarly, Mohawk men who were occupationally exposed to PCBs were more likely than those without occupational exposure to have a serum PCB congener pattern that was similar to that of Aroclor 1248, the commercial PCB mixture used locally. The serum PCB congener pattern of Raquette Point residents more closely resembled the pattern in outdoor air only if the men ate relatively few local fish. The study is among the first to demonstrate that outdoor air may affect serum PCB congener patterns, at least in the absence of heavy fish consumption.