Fully organic, flexible, and biodegradable components for bioinspired electronics
Fully organic, flexible, and biodegradable components for bioinspired electronics
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DOI：
10.1117/12.2517804
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发表时间：
2019-05
影响因子：
3.2
通讯作者：
Meng Xu;Dr Sayantan Pradhan;R. Pal;V. Yadavalli
中科院分区：
文献类型：
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作者：
Meng Xu;Dr Sayantan Pradhan;R. Pal;V. Yadavalli
在过去的几年里，自然启发/衍生生物材料领域的进展已经彻底改变了下一代生物医学设备的生产，并将继续在该领域产生影响。特别令人感兴趣的是生物可降解材料在制造完全有机的、本质上柔性的薄膜器件中的应用。具有精确图案化的微米或纳米级电路的组件可以提供不同的功能，如微电极，生物传感器和超级电容器。优点包括在非平面生物界面处提供共形接触的能力，能够以可控的速率降解，以及在体内引起最小的反应。这些因素作为体内应用的可植入装置具有巨大的潜力，同时还通过固有的可降解性解决了对“电子废物”的担忧。这种柔性生物电子器件的制造需要仔细优化机械性能、导电性以及使用通常不容易适应这种工艺的材料的精确制造。特别感兴趣的一个选择是基于丝蛋白的生物相容性和生物可降解的柔性生物电子学的构建。在这项工作中，我们提出了光交联丝蛋白和导电聚合物的组合，以精确地制造用于感兴趣的不同目标的传感的柔性设备。应用简单且可扩展的光刻技术来制造具有导电微图案的柔性衬底，这些图案显示出可调的电气和机械性能。具有竞争力的导电性，以及良好的生物相容性和可控的生物降解性。通过这项工作，探索了制造下一代完全有机的柔性生物电子器件的可能性。
Advances in the field of nature-inspired/derived biomaterials have been revolutionizing the production of next-generation biomedical devices over the past few years, and will continue to make impacts in the field. Of special interest is the application of biodegradable materials in the fabrication of fully organic, intrinsically flexible, thin film devices. Components with precisely patterned micro- or nano-scale circuits can provide different functions as microelectrodes, biosensors, and supercapacitors. Advantages include the ability to provide conformal contact at non-planar biointerfaces, being able to be degraded at controllable rate, and invoking minimal reactions within the body. These factors present great potential as implantable devices for in-vivo applications, while also addressing concerns with “electronic waste” by being intrinsically degradable. The fabrication of such flexible bioelectronics requires a careful optimization of mechanical properties, electrical conductivity, and precise fabrication using materials that are often not easily adapted to such processes. One option of particular interest is the construction of biocompatible and biodegradable, flexible bioelectronics based on silk proteins. In this work, we present the combination of photo-crosslinkable silk proteins and conductive polymers to precisely fabricate flexible devices for the sensing of different targets of interest. A facile and scalable photolithography is applied to fabricate flexible substrates with conductive micropatterns which show tunable electrical and mechanical properties. Competitive conductivity, as well as excellent biocompatibility and controllable biodegradability are shown. Through this work, the possibility of making next-generation, fully organic, flexible bioelectronics is explored.