Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients.
Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients.
复制标题
IL-33 通过调节痛风患者的脂质代谢来预防肾损伤的潜力
DOI：
10.1155/2016/1028401
复制
发表时间：
2016
影响因子：
4.3
通讯作者：
Shi G
中科院分区：
文献类型：
--
作者：
Duan L;Huang Y;Su Q;Lin Q;Liu W;Luo J;Yu B;He Y;Qian H;Liu Y;Chen J;Shi G
白细胞介素-33（IL-33）是最近发现的IL-1超家族成员，通过其特异性IL-1受体ST 2与包括自身免疫性疾病、脓毒症和变态反应在内的多种人类病理学相关。然而，关于IL-33在痛风中的作用的信息很少。在这项研究中，我们研究了IL-33在痛风患者中的潜在作用。采用ELISA法检测血清IL-33水平，并从病历系统中提取临床和实验室参数，血清肌酐、尿素和血脂。与健康对照组相比，痛风患者的血清IL-33表达主要增加，并且在无肾损伤的患者中IL-33水平更高。此外，IL-33与肾损伤的生物标志物如CRE和尿素呈负相关。脂代谢紊乱、痛风石、高血压是痛风性肾损害的常见原因。有趣的是，在LDL和HDL中分别观察到IL-33表达的负相关和正相关。而伴有高血压和痛风石的痛风患者则无明显变化。提示IL-33可能通过调节脂质代谢对痛风性肾损伤起保护作用。
Interleukin-33 (IL-33), the most recently discovered member of the IL-1 superfamily, has been linked to several human pathologies including autoimmune diseases, sepsis, and allergy through its specific IL-1 receptor ST2. However, there is little information regarding the role of IL-33 in gout. In this study, we investigated the potential role of IL-33 in gout patients. The serum level of IL-33 was measured by ELISA, and the clinical and laboratory parameters, serum creatinine, urea, and lipid, were extracted from medical record system. The serum IL-33 expression was predominantly increased in gout patients compared to healthy controls, and the IL-33 levels were higher in patients without kidney injury. Furthermore, IL-33 showed a negative correlation with biomarkers of kidney injury, such as CRE and urea. The lipid metabolism dysfunction, tophi, and hypertension are the common reasons for kidney injury in gout. Interestingly, inverse and positive correlation of IL-33 expression was observed in LDL and HDL, respectively. However, there was no significant alteration in the gout patients with hypertension and tophi. These data suggested that IL-33 might act as a protective role in kidney injury through regulating the lipid metabolism in gout.