Age-related mitochondrial dysfunction as a key factor in COVID-19 disease.
Age-related mitochondrial dysfunction as a key factor in COVID-19 disease.
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DOI：
10.1016/j.exger.2020.111147
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发表时间：
2020-12
影响因子：
3.9
通讯作者：
López-Lluch G
中科院分区：
文献类型：
--
作者：
Moreno Fernández-Ayala DJ;Navas P;López-Lluch G
SARS-CoV-2导致严重肺炎（COVID-19），主要影响老年人。在COVID-19中，巨噬细胞浸润到肺部引起快速和强烈的细胞因子风暴，最终导致多器官衰竭和死亡。代谢综合征、肥胖症、2型糖尿病、肺和心血管疾病等共病，都是与年龄相关的疾病，增加了COVID-19的严重程度和致命性。线粒体功能障碍是衰老和COVID-19风险因素的标志之一。线粒体功能障碍与对病毒感染和慢性炎症的免疫反应缺陷有关。这篇综述讨论了线粒体功能障碍如何与衰老和不同年龄相关疾病中的免疫反应缺陷相关，以及与COVID-19进展中预后不良相关的许多合并症。我们认为，线粒体功能障碍引起的慢性炎症是导致炎症细胞因子爆炸性释放的原因，导致COVID-19患者严重肺炎、多器官衰竭，最终死亡。基于改善线粒体更新、动力学和活性的疗法的预防性治疗对于预防COVID-19的严重程度至关重要。线粒体功能障碍与衰老、年龄相关疾病和代谢综合征有关。线粒体的不平衡活性参与炎症和对病毒感染的功能障碍反应。COVID-19在老年人和代谢综合征相关疾病中的严重程度较高。衰老过程中线粒体活性的改善可以改善对包括呼吸道病毒在内的病毒感染的反应。减少功能失调的线粒体可以减少对SARS-CoV-2感染的炎症反应。
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity. Mitochondrial dysfunction is associated with aging and age-related diseases and metabolic syndrome. Unbalanced activity of mitochondria is involved in inflammation and dysfunctional response to virus infection. COVID-19 severity is higher in aged and metabolic syndrome related diseases. Improvement of mitochondrial activity during aging can improve response to virus infections including respiratory virus. Reduction of dysfunctional mitochondria can reduce the inflammatory response to SARS-CoV-2 infection.
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
Casanova JL
DOI：
10.1097/mco.0000000000000444
发表时间：
2018-03
影响因子：
3.1
作者：
Beijers RJHCG;Gosker HR;Schols AMWJ
通讯作者：
Schols AMWJ
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
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Pulendran B
影响因子：
2.2
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Tikoo SK
影响因子：
64.8
作者：
Baur, Joseph A.;Pearson, Kevin J.;Sinclair, David A.
通讯作者：
Sinclair, David A.