Effect of estrogen on cerebral glucose metabolism in postmenopausal women
Effect of estrogen on cerebral glucose metabolism in postmenopausal women
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DOI：
10.1212/wnl.55.6.875
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发表时间：
2000-09-26
期刊：
影响因子：
9.9
通讯作者：
Jagust, WJ
中科院分区：
文献类型：
--
作者：
Eberling, JL;Reed, BR;Jagust, WJ
PET被用来评估绝经后妇女使用雌激素对局部脑葡萄糖代谢的影响。对接受雌激素替代疗法（ERT+）的妇女、未接受雌激素（ERT-）的妇女和AD妇女进行了研究。ERT-组显示的代谢率介于ERT+组和AD组之间，但未显示任何认知障碍体征。这些发现表明雌激素消耗对大脑代谢活动的影响。
PET was used to evaluate the effect of estrogen use on regional cerebral glucose metabolism in postmenopausal women. Women receiving estrogen replacement therapy (ERT+), women not receiving estrogen (ERT-), and women with AD were studied. The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity.