Inhibition by prolactin of post-castration rise in LH.
Inhibition by prolactin of post-castration rise in LH.
复制标题
催乳素对去势后 LH 升高的抑制。
作者：
L. Grandison;C. Hodson;H. T. Chen;J. Advis;J. Simpkins;J. Meites
雄性和雌性大鼠去势后血清LH明显升高。通过注射催乳素（Prl）、少量Prl植入正中隆起（ME）、在肾包膜下移植2个垂体前叶（APs）或在皮肤下移植分泌Prl的垂体瘤，可部分或完全阻止血清LH升高。垂体瘤移植物体积越大，Prl分泌越多，其抑制LH释放的效果越好。不同处理对LH释放的抑制一般在早期大于后期。切除卵巢的大鼠垂体LH对合成LH- rh的反应与未移植垂体的大鼠相同，垂体移植可阻止垂体切除后下丘脑LH- rh的下降。这些结果表明，Prl可以抑制去势后黄体生成素的释放，这种作用是通过下丘脑介导的。
Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by transplantation of a Prl-secreting pituitary tumor underneath the skin. The larger pituitary tumor transplants secreted more Prl and were more effective in reducing LH release than the smaller tumors which secreted less Prl. Suppression of LH release generally was greater during the earlier than in the later phases of the different treatments. The pituitary LH response to synthetic LH-RH was the same in ovariectomized rats with or without pituitary grafts, and the decrease in hypothalamic LH-RH after orchidectomy was prevented by pituitary grafts. These results indicate that Prl can depress LH release after castration and that these effects are mediated via the hypothalamus.