Cohort Profile: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Cohort Profile: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
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DOI：
10.1093/ije/dyu084
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发表时间：
2015-04-01
影响因子：
7.7
通讯作者：
Yoneshima, Hideo
中科院分区：
文献类型：
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作者：
Iki, Masayuki;Tamaki, Junko;Yoneshima, Hideo
日本基于人群的骨质疏松症（JPOS）队列研究于1996年启动，旨在通过双能X线吸收测定法（DXA）和骨转换标志物在日本女性人群中建立面积骨矿物质密度（aBMD）的参考数据库，并确定骨质疏松性骨折的风险因素。在基线时，随机选择3984名年龄在15至79岁之间的女性，以提供代表性的骨状态数据和aBMD值，用于诊断骨质疏松症。在1999年、2002年、2006年和2011/12年进行了随访调查，以确定aBMD的变化，并确定经形态测定证实的椎骨骨折和临床骨折。这些结果是从2174名至少参加了一次随访调查的妇女中获得的。JPOS是一个独特的个人水平的骨健康信息资源，具有放射学和生物学档案，包括DXA图像，血清，血浆和DNA，用于未来新兴的放射学和生物学技术的分析。JPOS数据集不是免费提供的，但鼓励新的合作。请潜在的合作者与秘书长（M.I.）联系。在JPOS研究小组的行政办公室。
The Japanese Population-based Osteoporosis (JPOS) Cohort Study was launched in 1996 to produce a reference database of areal bone mineral density (aBMD) by dual energy X-ray absorptiometry (DXA) and bone turnover markers in the Japanese female population and to determine risk factors for osteoporotic fractures. At baseline, 3984 women aged 15 to 79 years were randomly selected to provide representative bone status data and aBMD values for the diagnosis of osteoporosis. Follow-up surveys were conducted in 1999, 2002, 2006 and 2011/12 to determine changes in aBMD and identify incident morphometry-confirmed vertebral fractures and clinical fractures. These outcomes were obtained from 2174 women who participated in at least one follow-up survey. JPOS is a unique resource of individual-level bone health information with radiological and biological archives that include DXA images, and serum, plasma and DNA for future analyses with emerging radiological and biological techniques. The JPOS dataset is not freely available, but new collaborations are encouraged. Potential collaborators are invited to contact the Secretary General (M.I.) at the administrative office of the JPOS Study Group.