Neuropathic pain sensations are differentially sensitive to dextrorphan
Neuropathic pain sensations are differentially sensitive to dextrorphan
复制标题
神经性疼痛感觉对右啡烷的敏感性不同
作者：
Michael Tal;Gary J. Bennett
Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano- allodynia. Previous work has shown that the heat- hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.
