Improving our resolution of kidney morphogenesis across time and space
Improving our resolution of kidney morphogenesis across time and space
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DOI：
10.1016/j.gde.2015.03.001
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发表时间：
2015-06-01
影响因子：
4
通讯作者：
Little, Melissa H.
中科院分区：
文献类型：
--
作者：
Little, Melissa H.
与许多哺乳动物器官一样，大小和细胞复杂性对肾脏器官发生的综合分析提出了相当大的挑战。对小鼠的传统分析揭示了早期模式事件和空间细胞关系。然而，对后来的事件缺乏了解。肾脏发育过程中基因表达的全面时空图谱的产生促进了谱系定义的进步，以及选择性室消融。定量和动态成像技术的进步，使得肾脏器官发生过程中器官、组成组织和细胞水平的综合分析成为可能。这些方法将增强我们对肾脏发育和最终出生后器官功能之间联系的理解。最后的前沿将是将这种理解转化为人类肾脏疾病的结果。
As with many mammalian organs, size and cellular complexity represent considerable challenges to the comprehensive analysis of kidney organogenesis. Traditional analyses in the mouse have revealed early patterning events and spatial cellular relationships. However, an understanding of later events is lacking. The generation of a comprehensive temporospatial atlas of gene expression during kidney development has facilitated advances in lineage definition, as well as selective compartment ablation. Advances in quantitative and dynamic imaging have allowed comprehensive analyses at the level of organ, component tissue and cell across kidney organogenesis. Such approaches will enhance our understanding of the links between kidney development and final postnatal organ function. The final frontier will be translating this understanding to outcomes for renal disease in humans.