Plasticity of some spinal dorsal horn neurons as revealed by pentobarbital-induced disinhibition.
Plasticity of some spinal dorsal horn neurons as revealed by pentobarbital-induced disinhibition.
复制标题
戊巴比妥诱导的去抑制揭示了一些脊髓背角神经元的可塑性。
DOI：
10.1016/0006-8993(90)90863-7
复制
发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Tang,J
中科院分区：
文献类型：
--
作者：
Collins,JG;Ren,K;Saito,Y;Iwasaki,H;Tang,J
记录细胞外活性从单个脊髓背角神经元在生理上完整的，清醒的，无药物猫之前和之后的静脉注射20毫克/公斤戊巴比妥（铅）。铅引起了一系列反应特性的变化，反映了一些脊髓背角神经元明显的瞬间可塑性。铅管理揭露了一些低阈值（LT）神经元的能力，以响应有害的机械或热刺激，导致他们被重新归类为宽动态范围（WDR）神经元。铅也出现了揭露后放电在一些神经元伤害性的机械刺激。此外，一些神经元似乎能够更好地信号强度的机械刺激后铅的变化。在许多情况下，低阈值刺激的神经元感受野减少，但也观察到扩大。部分神经元对外周刺激的反应不受铅的影响。我们假设，在研究中使用的相对低剂量的铅减少了一些脊髓背侧神经元的紧张性抑制，虽然观察到的效果可能是由兴奋产生的。
Extracellular activity was recorded from single spinal dorsal horn neurons in physiologically intact, awake, drug-free cats before and after the intravenous administration of 20 mg/kg pentobarbital (Pb). Pb produced a series of changes in response properties that reflect a significant moment-to-moment plasticity of some spinal dorsal horn neurons. Pb administration unmasked the ability of some low-threshold (LT) neurons to respond to noxious mechanical or thermal stimuli resulting in their being reclassified as wide dynamic range (WDR) neurons. Pb also appeared to unmask an afterdischarge in some neurons following noxious mechanical stimulation. In addition, some neurons appeared to be better able to signal changes in the intensity of mechanical stimulation after Pb. Neuronal receptive fields for low-threshold stimulation were reduced in many instances but enlargement was also observed. The responses of some neurons to peripheral stimulation were unchanged by Pb. We hypothesize that the relatively low doses of Pb used in the study reduced tonic inhibition of some spinal dorsal neurons although the observed effects could have been produced by excitation.