Degradation of 3D-Printed Porous Polylactic Acid Scaffolds Under Mechanical Stimulus.
Degradation of 3D-Printed Porous Polylactic Acid Scaffolds Under Mechanical Stimulus.
复制标题
3D 打印多孔聚乳酸支架在机械刺激下的降解。
DOI：
10.3389/fbioe.2021.691834
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发表时间：
2021
影响因子：
5.7
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Chen H;Shi Q;Shui H;Wang P;Chen Q;Li Z
Polylactic acid (PLA) is a biodegradable polymer commonly used as a scaffold material to repair tissue defects, and its degradation is associated with mechanical stimulus. In this study, the effect of mechanical stimulus on the degradation of 3D-printed PLA scaffolds was investigated by in vitro experiments and an author-developed numerical model. Forty-five samples with porosity 64.8% were printed to carry out the degradation experiment within 90 days. Statistical analyses of the mass, volume fraction, Young’s modulus, and number average molecular weight were made, and the in vitro experiments were further used to verify the proposed numerical model of the scaffold degradation. The results indicated that the mechanical stimulus accelerated the degradation of the PLA scaffold, and the higher mechanical stimulus led to a faster degradation of the scaffolds at the late stage of the degradation process. In addition, the Young’s modulus and the normalized number average molecular weight of the PLA scaffolds between the experiments and the numerical simulations were comparable, especially for the number average molecular weight. The present study could be helpful in the design of the biodegradable PLA scaffolds.
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机械刺激对不同设计结构的聚乳酸支架降解的影响。
DOI：
10.1016/j.jmbbm.2019.04.028
发表时间：
2019-08-01
影响因子：
3.9
作者：
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通讯作者：
Li, Zhiyong
影响因子：
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Kaloshkin, S. D.
影响因子：
5.9
作者：
Yew, GH;Yusof, AMM;Ishiaku, US
通讯作者：
Ishiaku, US
影响因子：
9.7
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通讯作者：
Li, Qing
影响因子：
9.1
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通讯作者：
Verma, A