Is binocular competition essential for layer formation in the lateral geniculate nucleus?
Is binocular competition essential for layer formation in the lateral geniculate nucleus?
复制标题
双眼竞争对于外侧膝状核层的形成至关重要吗？
DOI：
10.1159/000116588
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Condo,GJ
中科院分区：
文献类型：
--
作者：
Casagrande,VA;Condo,GJ
在本文中，我们研究的机制，可以解释如何层内形成的外侧膝状体核（LGN）。正常LGN的发展和发展的实验或遗传干扰，一起分析，表明，双眼竞争的相互作用单独不能占无论是分离的retinogeniculate轴突或随后形成的细胞层。相反，它似乎更有可能的是，轴突的初始排序结果与不同的身份和差异的亲和力突触后LGN目标的轴突群体之间的活动依赖性的相互作用。然而，竞争性的相互作用可能有助于对相似类型的轴突进行分类或改善拓扑结构。我们还提出，LGN层形成的后续步骤，如层间空间的形成，取决于视网膜轴突，视网膜外轴突和LGN细胞的树突发育之间的相互作用的序列。
In this paper we examine mechanisms that could explain how layers form within the lateral geniculate nucleus (LGN). Analysis of normal LGN development and development following experimental or genetic perturbation, together, suggest that binocular competitive interactions alone cannot account for either the segregation of retinogeniculate axons or subsequent formation of cell layers. Instead, it appears more likely that initial sorting of axons results from an activity-dependent interaction between populations of axons with different identities and differential affinities for postsynaptic LGN targets. Competitive interactions, however, may aid in sorting axons of like type or in refining topography. We also propose that the subsequent steps in LGN layer formation, such as the formation of interlaminar spaces, depend upon a sequence of interactions between retinal axons, extraretinal axons and outgrowth of developing dendrites of LGN cells.