Human breast carcinomas: marker chromosomes involving 1q in seven cases.
Human breast carcinomas: marker chromosomes involving 1q in seven cases.
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人类乳腺癌：七例涉及 1q 的标记染色体。
DOI：
10.1159/000130716
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
R. Cailleau
中科院分区：
文献类型：
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作者：
Q. V. Cruciger;S. Pathak;R. Cailleau
在显带技术发明之前，肿瘤中染色体变化的分析遇到了两个主要障碍：（1）核型中许多染色体之间的形态相似性和（2）同一起源的个体癌症中无数的数量和结构变异。第一个困难已经通过捆绑技术基本上消除了。第二个问题可以通过检查同一组织的许多肿瘤来解决，以确定是否所有肿瘤都有一个或多个染色体异常。详细描述一个肿瘤细胞群体的所有染色体异常，虽然有用，但产生的结论不如发现大多数组织学相似的肿瘤中是否存在一个或多个“共同分母”标记。除了众所周知的慢性髓性白血病中的Ph 1染色体（NOWELL和Hungeri-ORD，1960;罗利，1973; ISHIHARA等，1974; Hayata等人，1975），在人脑膜瘤中发现了非随机染色体变化（MARK等，1972）、Burkitt淋巴瘤（MANOLOV和MANOLOVA，1972）和视网膜母细胞瘤（Wilson等，1973年）。
Prior to the inventions of banding techniques, analyses of chromosome changes in neoplasms encountered two major obstacles:(1) morphologi cal similarity among many chromosomes within a karyotype and (2) the myriad numerical and structural variations in individual cancers of the same origin. The first difficulty has been largely removed by the band ing techniques. The second problem can be tackled by examining a number of neoplasms of the same tissue to find out whether one or more chromosome anomalies are shared by all. To describe in detail all the chromosome anomalies of one tumor cell population, though useful, yields a less significant conclusion than to find if one or more “common denominator” markers exist among most histologically similar tumors. In addition to the well-known Ph1chromosome in chronic myelogenous leukemias (NOWELL and Hungeri-ORD, I960; ROWLEY, 1973; ISHIHARA et al., 1974; Hayata et al., 1975), nonrandom chromosome changes have been found in human meningiomas (MARK et al., 1972), Burkitt lympho mas (MANOLOV and MANOLOVA, 1972), and retinoblastomas (Wilson et al., 1973).