Structure and regulation of type II calcium/calmodulin-dependent protein kinase in central nervous system neurons.
Structure and regulation of type II calcium/calmodulin-dependent protein kinase in central nervous system neurons.
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DOI：
10.1101/sqb.1990.055.01.013
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
M. Kennedy;Mark K. Bennett;R. F. Bulleit;N. Erondu;V. R. Jennings;Stephen G. Miller;Sean S. Molloy;Bruce L. Patton;Leslie J. Schenker
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文献类型：
--
作者：
M. Kennedy;Mark K. Bennett;R. F. Bulleit;N. Erondu;V. R. Jennings;Stephen G. Miller;Sean S. Molloy;Bruce L. Patton;Leslie J. Schenker
In a recent talk at Caltech, David Baltimore suggested that molecular biology (the study of gene expression) and neurobiology are at similar stages. Both fields have identified many of the cast of important characters, but we still have much to learn about mechanisms and algorithms. In molecular neurobiology, the" mechanisms" are the ways that individual proteins work together to regulate release of transmitter or to modulate receptors and ion channels. The" algorithms" are the ways that these mechanisms are coordinated to allow neurons to maintain homeostasis, while at the same time adapting to changes in the external environment and storing information through molecular changes that alter the behavior of neural networks. In the last several years, the field of molecular neurobiology has appropriately placed great emphasis on identification of the relevant" characters." By characters, we mean the proteins that make up synaptic vesicles and other synaptic organelles, transmitter receptors, ion channels, and neuronal regulatory molecules. In this paper, we describe one character that we have studied for several years, called type II Ca++/calmodulin-dependent protein kinase (CaM kinase II). We then discuss an interesting mechanism by which this particular protein kinase may allow neurons to store information, if only for a short time. Finally, we describe an experimental system that we hope to use to learn how the CaM kinase, together with other neuronal proteins, participates in regulatory algorithms that are important for brain function.
