Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus
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DOI：
10.1016/j.diabres.2010.07.009
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发表时间：
2010-11-01
影响因子：
5.1
通讯作者：
Stephens, J. W.
中科院分区：
文献类型：
--
作者：
Jones, D. A.;Prior, S. L.;Stephens, J. W.
线粒体超氧化物歧化酶2(SOD2)是一种内源性抗氧化酶。Rs4880基因变异导致C>；T替换，影响超氧化物歧化酶活性。这种变异与糖尿病的微血管和大血管并发症有关。我们的目的是在糖尿病患者的横断面样本中检查该变异与冠心病(CHD)风险之间的关联。对776名患有糖尿病的高加索患者进行了基因分型。分析冠心病风险、氧化低密度脂蛋白和血浆总抗氧化状态(Taos)与基因型的关系。在女性中，TT型与CHD相关(CC/CT/TT：无CHD与CHD：22.4/56.0/21.6%与12.0/50.0/38.0%，p=0.03；CC/CT与TT，p=0.01)。与CC/CT相比，IT基因型与CHD相关的优势比为2.22[95%CI：1.17-4.24]，p=0.01。TT型还与血浆Taos显著降低相关。在男性中，未观察到基因型与CHD风险之间的关联，但CHD与年龄、低HDL值、高甘油三酯、高BMI和吸烟显著相关。在女性糖尿病患者中，该变异的TT型与CHD风险增加和血浆抗氧化防御降低相关。这种温和的基因效应在男性中并不明显，因为传统的风险因素可能会发挥更大的作用。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Mitochondrial superoxide dismutase 2 (SOD2) is an endogenous anti-oxidant enzyme. The rs4880 gene variant results in a C>T substitution, influencing SOD enzymatic activity. This variant has been associated with micro- and macro-vascular complications in diabetes mellitus. Our aim was to examine the association between this variant and coronary heart disease (CHD) risk in a cross-sectional sample of subjects with diabetes.776 Caucasian subjects with diabetes were genotyped. CHD risk, oxidised-LDL and plasma total anti-oxidant status (TAOS) were analysed in relation to genotype. In females, the TT genotype was associated with CHD (CC/CT/TT: No CHD vs. CHD: 22.4/56.0/21.6% vs. 12.0/50.0/38.0%, p = 0.03; for CC/CT vs. TT, p = 0.01). The odds ratio for CHD associated with the IT genotype compared to CC/CT was 2.22 [95%CI: 1.17-4.24], p = 0.01. The TT genotype was also associated with significantly lower plasma TAOS. In males, no association was observed between genotype and CHD risk, but CHD was significantly associated with age, lower HDL, higher triglycerides, higher BMI and cigarette smoking.The TT genotype of this variant is associated with increased CHD risk and lower plasma anti-oxidant defences in females with diabetes. This modest genotype-effect is not apparent in males where traditional risk factors may play a greater role. (C) 2010 Elsevier Ireland Ltd. All rights reserved.